An Evaluation of the Specificity of Executive Function Impairment in Developmental Psychopathology

Journal of the American Academy of Child and Adolescent Psychiatry
Lauren K WhiteRaquel E Gur

Abstract

Deficits in executive function (EF) are common in neuropsychiatric disorders, but the specificity of these deficits remains unclear. The aim of the present study was to elucidate the pattern of EF impairment across psychopathologies in children and adolescents. Associations among components of EF with dimensions of psychopathology, including an overall psychopathology factor, were assessed. Participants (8-21 years) were from the Philadelphia Neurodevelopmental Cohort (N = 9,498). Data from a structured clinical screening interview were reduced to 5 dimensional domains using factor analyses: overall psychopathology, anxious-misery, fear, externalizing, and psychosis. EF components of attentional vigilance, response inhibition, conceptual flexibility, and working memory were assessed. Associations of clinical dimensions with general EF ability and with specific EF components were examined. EF ability showed common and domain-specific associations with clinical symptoms. General EF was directly associated with the general psychopathology, anxious-misery, and psychosis domains but not with the fear or externalizing domains. For the EF subcomponents, differences emerged in the magnitude and direction of the association between comp...Continue Reading

Citations

Jul 19, 2019·Applied Neuropsychology. Child·Michele PolettiAndrea Raballo
Sep 26, 2019·Cognitive Therapy and Research·Hannah R SnyderBenjamin L Hankin
Jun 11, 2020·Translational Psychiatry·Suhua ChangStephen V Faraone
Apr 11, 2019·Development and Psychopathology·Elise M CardinaleDaniel S Pine
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Jutta S MayerChristine M Freitag
Feb 26, 2021·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Mark WadeCharles A Nelson
Mar 10, 2021·Research on Child and Adolescent Psychopathology·Mark WadeJennifer M Jenkins
Mar 20, 2021·Child Psychiatry and Human Development·Courtney A FilippiDaniel S Pine
Mar 27, 2021·Development and Psychopathology·Peter FonagyPatrick Luyten
Jan 16, 2019·Pediatrics·Jason D JonesRaquel E Gur

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