PMID: 6400922Oct 1, 1984Paper

An evaluation of the utility of four in vitro short term tests for predicting the cytotoxicity of individual compounds derived from tobacco smoke

Cell Biology and Toxicology
M CurvallB Pettersson

Abstract

An evaluation of results obtained earlier and now complemented to provide information on the activity of 305 compounds in four in vitro tests has been undertaken. Biological data based on the effects of these compounds on cell multiplication, oxidative metabolism, ciliary activity and membrane permeability are compared with a view to clarifying intersystem similarities and differences and, on the basis of a mean activity parameter, evaluating structure-activity and functionality-activity relationships. High mean activity is observed for 59 compounds, of which 18 are phenols, 14 aldehydes, 8 N-heterocyclics, 7 alcohols and 5 hydrocarbons. The medium and low mean activity groups comprise 105 and 131 members, respectively, and both include representatives of all functionalities examined. Delineation of the 305 compounds using 45 descriptors, and computer-assisted matching of these and any combination of them against the mean activity showed the most toxic single descriptor group to be terpenoids followed by indoles and naphthalenes, and the most toxic two-descriptor group to be alpha,beta-unsaturated carbonyls followed by n-alkyl alcohols, aldehydes and acids. Examination of intersystem similarities and differences, using a high-m...Continue Reading

Citations

Feb 1, 1991·Alcoholism, Clinical and Experimental Research·A Helander, M Curvall
Apr 7, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J CocchiaraA M Api
Apr 7, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C S LetiziaA M Api
Feb 23, 2012·Chemical Research in Toxicology·Hans-Juergen Haussmann
May 29, 2018·Organic & Biomolecular Chemistry·Rahul NisalJeet Kalia
May 2, 2009·Archives of Insect Biochemistry and Physiology·Yanxue YuXingbo Zhao
Jan 1, 1994·Critical Reviews in Microbiology·Y u PolotskyT h Khavkin

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