PMID: 9192926Jun 1, 1997Paper

An evaluation of two aerosol delivery systems for rhDNase

The European Respiratory Journal
P L ShahM E Hodson

Abstract

Increasingly, proteins are delivered to the respiratory tract as an aerosol, and clinical efficacy is dependent on optimal delivery of the protein in an intact form. The object of this study was to compare the in vivo and in vitro results of two aerosol delivery systems for the aerosolization of recombinant human deoxyribonuclease I (rhDNase) in patients with cystic fibrosis (CF). Patients with CF who were to be initiated on rhDNase were randomized either to the Hudson nebulizer and Pulmo-Aide compressor or to the Sidestream nebulizer driven by the CR50 air compressor. An in vitro study was performed in six sets of the two aerosol delivery systems. One hundred and seventy three patients were randomized in this open study, where rhDNase was administered for 7 days. Improvements in pulmonary function were observed in both groups following 1 week of therapy with rhDNase. Changes in the Sidestream/CR50 and Hudson/Pulmo-Aide groups, respectively, were: 16 and 11% for forced expiratory volume in one second (p=0.14); 12 and 10% for forced vital capacity (p=0.70); and 14 and 7% for forced expiratory flow at 25-75% of expiration (FEF(25-75)) (p=0.18). A greater proportion of patients in the Sidestream/CR50 group (58%) had a >10% respons...Continue Reading

Citations

Sep 30, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T A StandaertA B Montgomery
Aug 10, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T A StandaertB Ramsey
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·David GellerC Michael Bowman
Jan 10, 2008·AAPS PharmSciTech·Jolyon MitchellHak-Kim Chan
Jun 30, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Harry HeijermanUNKNOWN consensus working group
May 2, 2013·The Cochrane Database of Systematic Reviews·Tracey DanielsPaul Whitaker
Dec 1, 2007·Expert Review of Respiratory Medicine·E M Bakker, H A W M Tiddens
Sep 7, 2018·The Cochrane Database of Systematic Reviews·Connie Yang, Mark Montgomery
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J HendersonC R Wolf
Sep 16, 2014·Current Opinion in Pulmonary Medicine·Diana Bilton, Gemma Stanford
Apr 5, 2016·The Cochrane Database of Systematic Reviews·Connie YangSarah J Nolan
Mar 19, 2021·The Cochrane Database of Systematic Reviews·Connie Yang, Mark Montgomery

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