An event-related fMRI study of self-paced alphabetically ordered writing of single letters

Experimental Brain Research
I RektorP Krupa

Abstract

The spatial location of activation for writing individual letters and for writing simple dots was studied using event-related functional MRI. Ten healthy right-handed subjects were scanned while performing two different protocols with self-paced repetitive movement. In the first protocol with self-paced dot writing, we observed significant activation in regions known to participate in motor control: contralateral to the movement in the primary sensorimotor and supramarginal cortices, the supplementary motor area (SMA) with the underlying cingulate, in the thalamus and, to a lesser extent, in the ipsilateral inferior parietal and occipital cortices. In the second protocol, we investigated an elemental writing feature--writing single letters. We observed statistically significant changes in the premotor, sensorimotor and supramarginal cortices, the SMA and the thalamus with left predominance, and in the bilateral premotor and inferior/superior parietal cortices. The parietal region that was active during the writing of single letters spanned the border between the parietal superior and inferior lobuli Brodmann area (BA 2, 40), deep in the intraparietal sulcus, with a surprising right-sided dominance. The direct comparison of the ...Continue Reading

References

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Citations

Sep 10, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Antonella ConteAlfredo Berardelli
Oct 4, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M BockováI Rektor
Dec 23, 2011·The European Journal of Neuroscience·Emily Segal, Michael Petrides
Jul 9, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Samuel PlantonJean-François Démonet
Jul 2, 2020·PloS One·Christos ChatzichristosSergios Theodoridis
Jan 7, 2020·Journal of Neural Transmission·Marek BartoňIvan Rektor

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