An evidence-based assessment for the association between long-term exposure to outdoor air pollution and the risk of lung cancer

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Wan-Shui YangLing Wang

Abstract

Although outdoor air pollution has been identified as carcinogenic to humans, the magnitude of the relative risk (RR) and the 95% confidence interval (CI) for lung cancer in relation to outdoor air pollution remain uncertain. On a global scale, we quantified the risk of lung cancer associated with long-term exposure to outdoor air pollution using a meta-analytic approach. Relevant cohort studies from two databases (PubMed and Web of Science) through 31 May 2014 were searched, and a total of 21 cohort studies were identified in the analysis. The risk of lung cancer mortality or morbidity increased 7.23 (95% CI: 1.48-13.31)%/10 μg/m increase in fine particles (PM2.5), 13.17 (95% CI: 5.57-21.30)%/10 parts per billion (ppb) increase in nitrogen dioxide (NO2), 0.81 (95% CI: 0.14-1.49)%/10 ppb increase in nitrogen oxides (NOx), and 14.76 (95% CI: 1.04-30.34)%/10 ppb increase in sulfur dioxide (SO2). These positive associations remained when analysis was restricted to never-smokers or studies with high methodological quality, and showed no difference by sex. In addition, the association of fine particles with lung cancer was suggestively stronger among never-smokers (RR per each 10 μg/m=1.18, 95% CI: 1.06-1.32). There was a null assoc...Continue Reading

Citations

Feb 6, 2016·International Journal of Environmental Research and Public Health·Nicole Bijlsma, Marc M Cohen
Aug 28, 2018·Journal of the Air & Waste Management Association·Yaru WangJun Chen
Sep 9, 2017·Environmental Health Perspectives·Michelle C TurnerSusan M Gapstur
Jul 27, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Dimitra Sifaki-PistollaUNKNOWN Cancer Registry of Crete (CRC)
Feb 29, 2020·International Journal of Environmental Research and Public Health·Huagui GuoJiansheng Wu
Nov 25, 2018·International Journal of Environmental Research and Public Health·Hong-Bae KimYong-Jae Lee
Jan 11, 2020·Frontiers in Oncology·Di LiangYutong He
Sep 2, 2015·ILAR Journal·Kun LuJames G Fox
Jul 4, 2017·Scandinavian Journal of Public Health·Miranda M FidlerIsabelle Soerjomataram
Feb 13, 2021·Environmental Pollution·Stéfane Dias RodriguesAdriano Mendonça Souza
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ashley K DoresScott B Patten
Mar 14, 2021·American Journal of Epidemiology·Maria Teresa LandiStephen J Chanock
Mar 19, 2021·Environmental Analysis, Health and Toxicology·Jae-Eun LeeYoung-Youl Kim

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R Foundation for Statistical Computing
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