Abstract
Several studies in the literature have investigated the possible role of the extent of lymphadenectomy in gastric cancer treatment failure. The current study attempted to determine the effectiveness and safety of lymphadenectomy with gastrectomy for the treatment of gastric cancer. Randomized controlled trials (RCTs) were identified by means of MEDLINE, EMBASE, Cochrane Controlled Trials Register databases, and Chinese Biomedical Database, as well as by selecting references from relevant articles. Overall, 14 RCTs (3,432 patients) were included in the meta-analysis. Of the D1 and D2 surgery groups, the operative mortality and postoperative morbidity were higher in the D2 group than in the D1 group, but the 3- and 5-year survival rates were not statistically different. Also the operative time was shorter in D1 compared to D2. In the D2 versus the D3 surgical group, the operative mortality, percentage of postoperative complications, operative time, and hospital stay were not significantly different. The results suggest that D2 and D3 surgery may not offer specific advantages for gastric cancer and instead may lead to disadvantages for patient outcomes.
References
Feb 1, 1988·The British Journal of Surgery·D M DentS K Price
Mar 1, 1981·The Japanese Journal of Surgery
Mar 25, 1995·Lancet·J J BonenkampC W Taat
Aug 1, 1994·Annals of Surgery·C S RobertsonA K Li
Mar 15, 1994·Cancer·T M BuntJ A Bruijn
Apr 13, 1996·Lancet·A CuschieriP Cook
Dec 11, 1997·The British Journal of Surgery·M Sasako
Mar 25, 1999·The New England Journal of Medicine·J J BonenkampUNKNOWN Dutch Gastric Cancer Group
Apr 2, 2002·The Journal of Surgical Research·Yuichi KasakuraTadatoshi Takayama
Apr 27, 2002·American Journal of Surgery·Jonathan L Meakins
Mar 19, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M DegiuliUNKNOWN Italian Gastric Cancer Study Group
Apr 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H H HartgrinkM Sasako
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takeshi SanoKunio Okajima
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C W WuJ Whang-Peng
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 1, 2006·The Lancet Oncology·Chew-Wun WuJacqueline Whang-Peng
Sep 2, 2006·Annals of Surgical Oncology·Jun Ho LeeJae-Moon Bae
Oct 20, 2006·The British Journal of Surgery·T YoshikawaS Yamamoto
Dec 6, 2006·Annals of Surgical Oncology·Toshimasa TsujinakaUNKNOWN Gastric Cancer Surgery Study Group of Japan Clinical Oncology Group
Dec 26, 2006·American Journal of Surgery·Jan KuligUNKNOWN Polish Gastric Cancer Study Group
Citations
Jan 31, 2013·Surgical Endoscopy·Lei JiangLiang Yao
Sep 15, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Savtaj S BrarNatalie Coburn
Dec 6, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Rajini SeevaratnamNatalie Coburn
Sep 12, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ichirota IinoHiroyuki Konno
Nov 26, 2013·Surgical Oncology·Zhou JunfengYu Peiwu
Dec 7, 2010·Cancer Treatment Reviews·F De VitaM Orditura
Oct 31, 2012·Annals of Surgery·Giuseppe BrisindaSerafino Vanella
Jun 23, 2010·BMC Cancer·Hao ZhangShubao Wang
Jul 16, 2010·World Journal of Gastroenterology : WJG·Alberto BiondiDomenico D'Ugo
Mar 6, 2010·World Journal of Gastroenterology : WJG·Zhen WangYun-Fei Cao
Apr 20, 2014·World Journal of Gastroenterology : WJG·Andrea GiulianiLuigi Basso
Apr 24, 2010·Surgical Endoscopy·Raffaele PuglieseFrancesco Pugliese
Feb 18, 2010·Journal of Cancer Research and Therapeutics·Melroy A D'souzaShailesh V Shrikhande
Feb 4, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R BiffiB Andreoni
Aug 24, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J KuligUNKNOWN Polish Gastric Cancer Study Group
Sep 29, 2009·Lancet·Patrick L ErginaJan Vandenbroucke
Oct 27, 2010·Journal of Surgical Oncology·Eelco de BreeDimitris D Tsiftsis
Mar 21, 2013·Journal of Surgical Oncology·Lei JiangJin-Hui Tian
May 5, 2009·American Journal of Surgery·Karem Slim, Corinne Vons
Feb 19, 2011·Magyar sebészet·F Tamás MolnárGyörgy Szekeres
Jun 1, 2015·World Journal of Surgical Oncology·Xiaoyuan Chu, Zhong-Fa Yang
Mar 31, 2015·Cancer Treatment Reviews·Simone Mocellin, Donato Nitti
May 6, 2014·Bulletin du cancer·Mathias AllinePhilippe Rouanet
Aug 22, 2014·Journal of Clinical Gastroenterology·Lei JiangJin-Hui Tian
Oct 4, 2014·World Journal of Gastroenterology : WJG·Giuseppe VerlatoGiovanni De Manzoni
Aug 13, 2015·The Cochrane Database of Systematic Reviews·Simone MocellinDonato Nitti
Mar 15, 2016·World Journal of Gastroenterology : WJG·Maurizio DegiuliMario Morino
May 10, 2018·Frontiers in Surgery·Gerassimos N Douridas, Stefanos K Pierrakakis
Nov 20, 2020·Khirurgiia·S I PaninA V Bykov
Mar 26, 2021·Cell Reports Medicine·Daxing XieJianping Gong