An evidence-based medicine review of lymphadenectomy extent for gastric cancer

American Journal of Surgery
Sun Hu YangNeel Sharma

Abstract

Several studies in the literature have investigated the possible role of the extent of lymphadenectomy in gastric cancer treatment failure. The current study attempted to determine the effectiveness and safety of lymphadenectomy with gastrectomy for the treatment of gastric cancer. Randomized controlled trials (RCTs) were identified by means of MEDLINE, EMBASE, Cochrane Controlled Trials Register databases, and Chinese Biomedical Database, as well as by selecting references from relevant articles. Overall, 14 RCTs (3,432 patients) were included in the meta-analysis. Of the D1 and D2 surgery groups, the operative mortality and postoperative morbidity were higher in the D2 group than in the D1 group, but the 3- and 5-year survival rates were not statistically different. Also the operative time was shorter in D1 compared to D2. In the D2 versus the D3 surgical group, the operative mortality, percentage of postoperative complications, operative time, and hospital stay were not significantly different. The results suggest that D2 and D3 surgery may not offer specific advantages for gastric cancer and instead may lead to disadvantages for patient outcomes.

References

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Citations

Sep 15, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Savtaj S BrarNatalie Coburn
Dec 6, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Rajini SeevaratnamNatalie Coburn
Sep 12, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ichirota IinoHiroyuki Konno
Oct 31, 2012·Annals of Surgery·Giuseppe BrisindaSerafino Vanella
Jul 16, 2010·World Journal of Gastroenterology : WJG·Alberto BiondiDomenico D'Ugo
Mar 6, 2010·World Journal of Gastroenterology : WJG·Zhen WangYun-Fei Cao
Apr 20, 2014·World Journal of Gastroenterology : WJG·Andrea GiulianiLuigi Basso
Feb 18, 2010·Journal of Cancer Research and Therapeutics·Melroy A D'souzaShailesh V Shrikhande
Feb 4, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R BiffiB Andreoni
Aug 24, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J KuligUNKNOWN Polish Gastric Cancer Study Group
Sep 29, 2009·Lancet·Patrick L ErginaJan Vandenbroucke
Oct 27, 2010·Journal of Surgical Oncology·Eelco de BreeDimitris D Tsiftsis
May 5, 2009·American Journal of Surgery·Karem Slim, Corinne Vons
Jun 1, 2015·World Journal of Surgical Oncology·Xiaoyuan Chu, Zhong-Fa Yang
Oct 4, 2014·World Journal of Gastroenterology : WJG·Giuseppe VerlatoGiovanni De Manzoni
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Mar 15, 2016·World Journal of Gastroenterology : WJG·Maurizio DegiuliMario Morino
May 10, 2018·Frontiers in Surgery·Gerassimos N Douridas, Stefanos K Pierrakakis

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