An Evidence-Based Review of Off-Label Uses of Polidocanol

Current Clinical Pharmacology
Seyyed Reza Sadat EbrahimiHossein Babaei

Abstract

Polidocanol is approved for its competence in the treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis and hemorrhoids. The two databases of MEDLINE and Cochrane Library were searched for all human English studies, published in January 2006 to November 2017, which contained the keyword of "polidocanol" or its alternative MeSH terms. Our search identified a total number of 597 articles. Those articles that were only discussing the approved uses of polidocanol were excluded and the remaining 116 articles were reviewed. Ele...Continue Reading

Citations

Nov 25, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ananta Khurana, Sinu Rose Mathachan

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