An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease

Clinical Medicine Insights. Gastroenterology
Meredith A SiglerKrystal L Edwards

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common complication in patients with metabolic syndrome. The role of statin therapy specifically for the treatment of NAFLD remains unknown. The aim of this review is to discuss outcomes of recent articles analyzing statin therapy in patients with NAFLD. A total of 12 trials met the inclusion criteria. Statins were not found to increase the prevalence of NAFLD once confounding variables were considered. Statins were also found to be beneficial in treating dyslipidemia and improving liver function. Histological liver outcomes in patients with NAFLD were controversial. One trial found a reduction in the incidence of hepatocellular carcinoma associated with the use of statins. Overall, therapy with statins appears to be safe for use in patients with NAFLD. Several trials have validated the use of statins for the treatment of dyslipidemia; however, it remains unknown as to whether statins should be used to specifically treat NAFLD.

References

Jul 16, 2014·World Journal of Gastroenterology : WJG·Maria Del BenFrancesco Angelico
Aug 4, 2015·Metabolism: Clinical and Experimental·Konstantinos TziomalosAsterios Karagiannis
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer

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Citations

Sep 27, 2018·Diseases·Umair IqbalAijaz Ahmed
Nov 25, 2020·International Journal of Molecular Sciences·Christopher MurphyAlvaro Garcia
Nov 3, 2020·TheScientificWorldJournal·Hamad Abdulsalam Hamad AlfarisiChe Anuar Che Mohamad
Mar 14, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Lillian Russo-Savage, Ira G Schulman
Dec 16, 2020·Clinical and Molecular Hepatology·Karn WijarnpreechaDonghee Kim
Apr 27, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Aishwarya VenkatasubramanianSivaramakrishnan Venkatabalasubramanian
May 16, 2021·Seminars in Liver Disease·Søren MøllerLise Lotte Gluud
Jul 3, 2021·International Journal of Molecular Sciences·Hana LastuvkovaStanislav Micuda
Aug 27, 2021·Current Oncology·Michelle C M LeeChristine Brezden-Masley

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Methods Mentioned

BETA
biopsy
biopsies

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