An Evidence-based Review of the Efficacy of Treatment Approaches for Immature Permanent Teeth with Pulp Necrosis

Journal of Endodontics
Bill KahlerLouis M Lin

Abstract

Two fundamental assumptions for teeth treated with regenerative endodontic procedures (REPs) are (1) that the clinical outcome is comparable with the traditional techniques of calcium hydroxide apexification and mineral trioxide aggregate apical barrier techniques and (2) that REPs will result in further root maturation. A systematic review of the electronic databases (Scopus, PubMed, and Web of Science) involved a search for studies that used quantitative assessments of root maturation. The search terms were "dental pulp," "regenerative endodontic therapy," "revascularization," and "revitalization." The identified studies were further screened for cohort studies that compared clinical outcomes between teeth treated with REPs and apexification/apical barrier approaches. The primary question under review was framed according to the population, exposure, and outcome format. Of the 368 studies identified by the search, 6 cohort studies used quantitative assessments of any further root maturation after REPs, and a subset of 4 of these cohort studies assessed and compared clinical outcomes between the different treatment approaches. Immature teeth with pulp necrosis treated with REPs generally show further root maturation although t...Continue Reading

Citations

Jan 18, 2018·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·F MasmoudiF Maatouk
May 28, 2020·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ashraf F FouadLiran Levin
Oct 12, 2017·Stem Cells International·Petra HilkensIvo Lambrichts
May 20, 2018·International Endodontic Journal·S G KimB Kahler
Dec 5, 2019·Brazilian Dental Journal·Giampiero Rossi-FedeleNagendrababu Venkateshbabu
Oct 24, 2020·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Andrea Cardoso PereiraAdriana de-Jesus-Soares
Nov 26, 2020·Brazilian Dental Journal·Claudio Maniglia-FerreiraFernanda Geraldo Pappen
Aug 4, 2020·International Journal of Clinical Pediatric Dentistry·Manisha BehlKirti Chaudhry
Jun 2, 2021·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Pınar Serdar EymirliEmel Uzunoğlu Özyürek
May 3, 2021·International Endodontic Journal·UNKNOWN European Society of Endodontology (ESE) developed by:K Galler
Mar 9, 2021·International Endodontic Journal·G KrastlK Galler
Nov 30, 2018·Journal of Endodontics·Bill KahlerLouis M Lin
Sep 9, 2020·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·George Bogen, Domenico Ricucci
Dec 5, 2021·International Endodontic Journal·Gabriel KrastlKerstin Galler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.