An evidence summary of the management of patients taking direct oral anticoagulants (DOACs) undergoing dental surgery

International Journal of Oral and Maxillofacial Surgery
Steven Johnston

Abstract

Direct oral anticoagulant (DOAC) drugs (dabigatran, rivaroxaban, and apixaban) have emerged in the last decade to overcome some of the drawbacks of existing medications. To date, little is known about the dental management of patients taking these drugs. This study was undertaken to establish the evidence for the management of patients undergoing dental procedures while taking these medications. A rapid review approach was used to identify clinical and scientific research related to dental surgery performed in patients taking DOACs in order to produce an evidence summary. The rapid review did not identify any systematic reviews or original clinical trials and the overall quality of evidence found was poor. Most of the literature consisted of non-structured review articles and guidance documents based on assumptions from non-dental data and expert opinion, and recommendations on best practice varied throughout. The findings from the review of the literature varied considerably. Currently, recommendations are based on poor quality scientific data and clinical trials are required to establish best evidence-based practice guidance.

References

Dec 16, 1998·Journal of the American College of Surgeons·M A QuaderB E Sumpio
Oct 23, 2003·The Journal of Biological Chemistry·Earl W Davie
Oct 31, 2008·ANZ Journal of Surgery·Amber WattGuy Maddern
Jan 1, 2010·The New England Journal of Medicine·Donald Stuart Houston, Ryan Zarychanski
Dec 24, 2010·The New England Journal of Medicine·Michael Rud LassenUNKNOWN ADVANCE-3 Investigators
Apr 6, 2011·Circulation·Graeme J Hankey, John W Eikelboom
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Apr 5, 2012·American Journal of Hematology·Scott KaatzJack Ansell
May 17, 2012·Systematic Reviews·Sara KhanguraDavid Moher
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·F John Firriolo, Wendy S Hupp
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·James W Little
Jun 29, 2012·BMJ : British Medical Journal·Lee-Yee ChongUNKNOWN Guideline Development Group
Aug 11, 2012·British Dental Journal·M Griffiths, C Scully
Sep 28, 2012·Thrombosis and Haemostasis·Alexander G G TurpieSylvia Haas
Oct 27, 2012·British Dental Journal·R Davies
Nov 14, 2012·Circulation·Jeffrey I WeitzJohn W Eikelboom
Jan 12, 2013·British Dental Journal·M de Mendonca
Jan 19, 2013·Clinical Therapeutics·Tyan F ThomasSarah A Spinler
Feb 8, 2013·Seminars in Thrombosis and Hemostasis·Cristhiam M Rojas-Hernandez, David A Garcia
Mar 12, 2013·Blood·Felix SchieleTobias Litzenburger
Mar 26, 2013·Medicina oral, patología oral y cirugía bucal·Hamid-Reza FakhriJukka-H Meurman
Apr 4, 2013·Stroke; a Journal of Cerebral Circulation·Amanda R HarringtonDaniel C Malone
Apr 30, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hein HeidbuchelUNKNOWN European Heart Rhythm Association
May 11, 2013·British Dental Journal·R KerrG Sime
May 21, 2013·Internal and Emergency Medicine·Vittorio Pengo
Jul 13, 2013·British Dental Journal·O J Rider, E B Rider
Jul 16, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Kelli K RomondRobert G Henry
Aug 10, 2013·British Dental Journal·C Scully
Sep 3, 2013·The New England Journal of Medicine·Harry R BüllerPhil Wells
Oct 15, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Denise E van DiermenJohan Hoogstraten

❮ Previous
Next ❯

Citations

Jul 27, 2017·The European Journal of General Practice·Csaba András DézsiAndrás Döme Dézsi
Feb 18, 2020·Australian Dental Journal·L TeohM J McCullough
Sep 8, 2017·Journal of Dental Anesthesia and Pain Medicine·Chihun KimWonse Park
Oct 1, 2016·Jornal Vascular Brasileiro·Winston Bonetti Yoshida
Jul 2, 2020·International Journal of Environmental Research and Public Health·Guido GallettiAntonio Barone
Jul 24, 2020·Minerva stomatologica·Amanda RochaTarcilia Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved