The transition to multicellularity, recognized as one the major transitions in evolution, has occurred independently several times. While multicellular development has been extensively studied in zygotic organisms including plant and animal groups, just a few aggregative multicellular organisms have been employed as model organisms for the study of multicellularity. Studying different evolutionary origins and modes of multicellularity enables comparative analyses that can help identifying lineage-specific aspects of multicellular evolution and generic factors and mechanisms involved in the transition to multicellularity. Among aggregative multicellular organisms, myxobacteria are a valuable system to explore the particularities that aggregation confers to the evolution of multicellularity and mechanisms shared with clonal organisms. Moreover, myxobacteria species develop fruiting bodies displaying a range of morphological diversity. In this review, we aim to synthesize diverse lines of evidence regarding myxobacteria development and discuss them in the context of Evo-Devo concepts and approaches. First, we briefly describe the developmental processes in myxobacteria, present an updated comparative analysis of the genes involved...Continue Reading
Morphogenetic movements and multicellular development in the fruiting Myxobacterium, Stigmatella aurantiaca
Prey-derived signals regulating duration of the developmental growth phase of Bdellovibrio bacteriovorus
Morphogenetic effects of light and guanine derivatives on the fruiting myxobacterium Stigmatella aurantiaca
Guanosine pentaphosphate and guanosine tetraphosphate accumulation and induction of Myxococcus xanthus fruiting body development
Development in one dimension: the rapid differentiation of Dictyostelium discoideum in glass capillaries
devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus
Myxococcus xanthus sasS encodes a sensor histidine kinase required for early developmental gene expression
Identification and characterization of spdR mutations that bypass the BsgA protease-dependent regulation of developmental gene expression in Myxococcus xanthus
The act operon controls the level and time of C-signal production for Myxococcus xanthus development
Genetic studies of mrp, a locus essential for cellular aggregation and sporulation of Myxococcus xanthus
Light-induced carotenogenesis in Myxococcus xanthus: evidence that CarS acts as an anti-repressor of CarA
Characterization and description of Anaeromyxobacter dehalogenans gen. nov., sp. nov., an aryl-halorespiring facultative anaerobic myxobacterium
Coupling gene expression and multicellular morphogenesis during fruiting body formation in Myxococcus xanthus
Light-induced carotenogenesis in Myxococcus xanthus: functional characterization of the ECF sigma factor CarQ and antisigma factor CarR
Identification of an activator protein required for the induction of fruA, a gene essential for fruiting body development in Myxococcus xanthus
Identification of the C-signal, a contact-dependent morphogen coordinating multiple developmental responses in Myxococcus xanthus
Modulating factors for the Pkn4 kinase cascade in regulating 6-phosphofructokinase in Myxococcus xanthus
Identification of a protein Ser/Thr kinase cascade that regulates essential transcriptional activators in Myxococcus xanthus development
A protein Ser/Thr kinase cascade negatively regulates the DNA-binding activity of MrpC, a smaller form of which may be necessary for the Myxococcus xanthus development
Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator
Dynamical patterning modules: physico-genetic determinants of morphological development and evolution
The dynamics of developmental system drift in the gene network underlying wing polyphenism in ants: a mathematical model
Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological differentiation
Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus
Hdsp, a horizontally transferred gene required for social behavior and halotolerance in salt-tolerant Myxococcus fulvus HW-1
Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes
A cascade of coregulating enhancer binding proteins initiates and propagates a multicellular developmental program
Experimentally guided computational model discovers important elements for social behavior in myxobacteria
CarF mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX, in Myxococcus xanthus light-induced carotenogenesis
Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis
Evolution of regulatory networks: nematode vulva induction as an example of developmental systems drift
The wing-patterning network in the wingless castes of Myrmicine and Formicine ant species is a mix of evolutionarily labile and non-labile genes
Multicellularity arose several times in the evolution of eukaryotes (response to DOI 10.1002/bies.201100187)
Evolution of multicellularity coincided with increased diversification of cyanobacteria and the Great Oxidation Event
The stringent response controls catalases in Pseudomonas aeruginosa and is required for hydrogen peroxide and antibiotic tolerance
Experimental evolution of an alternating uni- and multicellular life cycle in Chlamydomonas reinhardtii
Molecular recognition in myxobacterial outer membrane exchange: functional, social and evolutionary implications
The CarD/CarG regulatory complex is required for the action of several members of the large set of Myxococcus xanthus extracytoplasmic function σ factors
Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility
Vulgatibacter incomptus gen. nov., sp. nov. and Labilithrix luteola gen. nov., sp. nov., two myxobacteria isolated from soil in Yakushima Island, and the description of Vulgatibacteraceae fam. nov., Labilitrichaceae fam. nov. and Anaeromyxobacteraceae fam. nov
Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians
Identification of a mutant locus that bypasses the BsgA protease requirement for social development in Myxococcus xanthus
Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach
Cell-cycle progress in obligate predatory bacteria is dependent upon sequential sensing of prey recognition and prey quality cues
Interplay between type IV pili activity and exopolysaccharides secretion controls motility patterns in single cells of Myxococcus xanthus
Complete Genome Sequence of the Fruiting Myxobacterium Myxococcus macrosporus Strain DSM 14697, Generated by PacBio Sequencing
Multicellular growth of the Basidiomycota phytopathogen fungus Sporisorium reilianum induced by acid conditions
Dynamical patterning modules and network motifs as joint determinants of development: Lessons from an aggregative bacterium
Plastic multicellular development of Myxococcus xanthus : genotype-environment interactions in a physical gradient
Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity
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