An evolution-based hypothesis on the origin and mechanisms of autoimmune disease

Immunology and Cell Biology
G W Boyd

Abstract

The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals of appropriate major histocompatibility type, leads to autoimmune disease. Such a view requires a slight adjustment to traditional ways of seeing Darwinian evolution, but one which makes real sense of the MHC-restricted nature of the adaptive immune response.

References

Jun 28, 1975·Lancet·P C Doherty, R M Zinkernagel
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·G J TodaroC J Sherr
Dec 1, 1992·Current Opinion in Genetics & Development·C Schmid, R Maraia
Sep 11, 1992·Trends in Genetics : TIG·P L DeiningerM H Edgell
Dec 30, 1991·Science·B A DombroskiH H Kazazian
Feb 1, 1991·Journal of Molecular Evolution·J Jurka, A Milosavljevic
Oct 1, 1991·Journal of Molecular Evolution·M R ShenP L Deininger
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·F Homo-DelarcheM Dardenne
Oct 25, 1990·Nucleic Acids Research·A G MateraC W Schmid
Jan 1, 1985·International Review of Cytology·J H Rogers
Mar 1, 1989·The Quarterly Review of Biology·R F DoolittleM A McClure
Apr 1, 1989·Trends in Genetics : TIG·D J Finnegan
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R H Miller, W S Robinson
Oct 1, 1985·Journal of the American Academy of Dermatology·C M Ridley
Jan 1, 1974·Pathology·F M Burnet
Sep 26, 1970·Nature·N G Anderson
Jul 14, 1983·Nature·H Varmus
Apr 17, 1980·Nature·W F Doolittle, C Sapienza
Apr 11, 1980·Science·M S Crane, J A Dvorak
Mar 26, 1982·Science·J HollandS VandePol
Apr 17, 1980·Nature·L E Orgel, F H Crick
Sep 1, 1994·Medical Microbiology and Immunology·O RottE Cash
Jan 1, 1995·Annual Review of Immunology·R L Wilder
Apr 1, 1995·Immunology and Cell Biology·H S Rothenfluh
Jan 1, 1995·Molecular and Cellular Biology·D H KassP L Deininger
May 1, 1994·The Tohoku Journal of Experimental Medicine·M F GourleyA D Steinberg
Jan 1, 1995·Viral Immunology·A D Cohen, Y Shoenfeld
Jan 1, 1996·Journal of Molecular Evolution·E Zietkiewicz, D Labuda
Jan 1, 1996·Clinical Microbiology Reviews·H B Urnovitz, W H Murphy
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·E NadirS A Ben-Sasson

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Citations

Jul 6, 2001·Scandinavian Journal of Immunology·F Monneaux, S Muller
Nov 4, 2008·Mutation Research·Sandra E Gomez-MejibaDario C Ramirez
Jul 16, 2008·Autoimmunity Reviews·Biji T Kurien, R Hal Scofield
Jul 25, 2000·The Journal of Infection·A M Denman
Dec 23, 2017·GeroScience·Joanna M S DaviesKelvin J A Davies
May 11, 2005·Scandinavian Journal of Immunology·B T KurienR H Scofield

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.