An evolutionary and developmental biology approach to gastroschisis

Birth Defects Research
John M OpitzLorenzo D Botto

Abstract

Recent advances have now made it possible to speak of gastroschisis narrowly in morphogenetic terms invoking the Rittler-Beaudoin (R-B) model. This proceeds from the appreciation of gastroschisis as a congenital intestinal herniation (without cover or liver) within the primordial umbilical ring, mostly to the right side of a normally formed umbilical cord. Presently, it is unresolved whether this visceral prolapse represents failure of ring closure before return of the physiological hernia into the abdomen or rupture of the delicate amniotic/peritoneal membrane at the ring's edge to the right of the cord. Animal observations and experiments will be required to address this question effectively. If gastroschisis is, in fact, a primary malformation with the primordial umbilical ring as the developmental field involved, then homology implies potential gastroschisis in all amniotes with corresponding nourishment from yolk sac (aka omphalomesenteric) vessels going into the embryo and excretory products out via the ancient umbilical connection. It also implies homology of corresponding morphogenetic signal transduction cascades. We review the history of gastroschisis, its presumed pathogenesis, and the developmental biology of the am...Continue Reading

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Citations

Mar 30, 2019·Birth Defects Research·Mark Lubinsky
Aug 7, 2019·Birth Defects Research·Marcia L FeldkampNicola J Camp
Jan 18, 2020·Occupational and Environmental Medicine·Nynke SpinderJennita Reefhuis
May 15, 2020·Birth Defects Research·Arimatias RaitioIlkka Helenius
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Aug 8, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Natasha T LogsdonLuciano Alves Favorito
Dec 18, 2020·Prenatal Diagnosis·Amanda Brasil de FreitasMaria de Lourdes Brizot
Feb 14, 2021·Communications Biology·Marco GinzelDietrich Kluth
Dec 23, 2020·Children·Vishwanath BhatVineet Bhandari
Nov 19, 2020·American Journal of Medical Genetics. Part a·Kaylee B ParkWilliam B Dobyns
Mar 29, 2021·Jornal de pediatria·Virginia Maria MunizEliana Zandonade
Apr 20, 2021·Birth Defects Research·Danielle K BourqueChristine M Armour
Apr 22, 2021·American Journal of Medical Genetics. Part a·Claude StollMarie-Paule Roth
Jun 22, 2021·Jornal de pediatria·Juliana Zoboli Del BigioFelipe Yu Matsushita

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