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An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences

Nature Genetics

Dec 19, 2018

Brad Gulko, Adam Siepel

Abstract

Here we ask the question "How much information do epigenomic datasets provide about human genomic function?" We consider nine epigenomic features across 115 cell types and measure information about function as a reduction in entropy under a probabilistic evolutionary model fitted to hum...read more

Mentioned in this Paper

Nonhuman primate
Genome
Question (Inquiry)
Primates
Gene Function
Base Sequence
SMPD2 gene
Epigenesis, Genetic
Febrile Neutropenia Without Clinically or Microbiologically Documented Infection With Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius
Epigenomics
100
2
1
79
Paper Details
References
  • References3
  • Citations1

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An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences

Nature Genetics

Dec 19, 2018

Brad Gulko, Adam Siepel

PMID: 30559490

DOI: 10.1038/s41588-018-0300-z

Abstract

Here we ask the question "How much information do epigenomic datasets provide about human genomic function?" We consider nine epigenomic features across 115 cell types and measure information about function as a reduction in entropy under a probabilistic evolutionary model fitted to hum...read more

Mentioned in this Paper

Nonhuman primate
Genome
Question (Inquiry)
Primates
Gene Function
Base Sequence
SMPD2 gene
Epigenesis, Genetic
Febrile Neutropenia Without Clinically or Microbiologically Documented Infection With Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius
Epigenomics
100
2
1
79

Similar Papers Found In These Feeds

Parasite evolution

Parasite evolution involves the heritable genetic changes that a parasite accumulates during its life time. Discover the latest research on parasite evolution here.

Related Papers

Journal of Molecular Evolution

Variation in protein structure and function: Primate hemoglobins

Journal of Molecular EvolutionDecember 1, 1972
B Sullivan
Nature

Natural selection and genetic drift in protein polymorphism

NatureSeptember 15, 1972
L Bullini, M Coluzzi
Paper Details
References
  • References3
  • Citations1
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