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An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences

Nature Genetics

Feb 17, 2019

Brad Gulko, Adam C Siepel

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Abstract

Here we ask the question "How much information do epigenomic datasets provide about human genomic function?" We consider nine epigenomic features across 115 cell types and measure information about function as a reduction in entropy under a probabilistic evolutionary model fitted to hum...read more

Mentioned in this Paper

Base Sequence
Genome
Genome, Human
Primates
Selection, Genetic
Variation (Genetics)
Nonhuman primate
Evolution, Molecular
Gene Function
Epigenesis, Genetic
98
2
1
70
Paper Details
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  • An evolutionary framework for measuring epigenomic information and estimating cell-type-specific fitness consequences

    Nature Genetics

    Feb 17, 2019

    Brad Gulko, Adam C Siepel

    PMID: 30559490

    DOI: 10.1038/s41588-018-0300-z

    Abstract

    Here we ask the question "How much information do epigenomic datasets provide about human genomic function?" We consider nine epigenomic features across 115 cell types and measure information about function as a reduction in entropy under a probabilistic evolutionary model fitted to hum...read more

    Mentioned in this Paper

    Base Sequence
    Genome
    Genome, Human
    Primates
    Selection, Genetic
    98
    2
    1
    70
    Paper Details
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