Apr 6, 2016

An evolutionary medicine perspective on Neandertal extinction

BioRxiv : the Preprint Server for Biology
Alexis P SullivanGeorge H Perry


The Eurasian sympatry of Neandertals and anatomically modern humans - beginning at least 45,000 years ago and lasting for more than 5,000 years - has long sparked anthropological interest into the factors that potentially contributed to Neandertal extinction. Among many different hypotheses, the "differential pathogen resistance" extinction model posits that Neandertals were disproportionately affected by exposure to novel infectious diseases that were transmitted during the period of spatiotemporal sympatry with modern humans. Comparisons of new archaic hominin paleogenome sequences with modern human genomes have confirmed a history of genetic admixture - and thus direct contact - between humans and Neandertals. Analyses of these data have also shown that Neandertal nuclear genome genetic diversity was likely considerably lower than that of the Eurasian anatomically modern humans with whom they came into contact, perhaps leaving Neandertal innate immune systems relatively more susceptible to novel pathogens. In this study, we compared levels of genetic diversity in genes for which genetic variation is hypothesized to benefit pathogen defense among Neandertals and African, European, and Asian modern humans, using available exom...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Gene Polymorphism
Genome-Wide Association Study
Immune System
Pathogenic Organism
Candidate Disease Gene
Extracellular Matrix Organization

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Journal of Human Evolution
Alexis P SullivanGeorge H Perry
BioRxiv : the Preprint Server for Biology
David ReherJanet Kelso
Genome Biology and Evolution
David ReherJanet Kelso
Proceedings of the National Academy of Sciences of the United States of America
S Mikko, L Andersson
Current Opinion in Genetics & Development
Floyd A Reed, Sarah A Tishkoff
© 2020 Meta ULC. All rights reserved