Oct 22, 2016

An evolutionary model of osteoarthritis including articular cartilage damage, and bone remodeling in a computational study

Journal of Biomechanics
Michael E StenderVirginia L Ferguson

Abstract

With osteoarthritis, a complex set of progressive chemical, biological, and mechanical changes occur in both cartilage and bone. The aim of this study is to develop a high-fidelity computational model of the complete bone-cartilage unit to study the evolution of osterarthritis-induced articular cartilage (AC) damage and remodeling of subchondral cortical bone (SCB) and subchondral trabecular bone (STB). A finite element model of spherical indentation was developed with a depth-dependent anisotropic model of degenerating articular cartilage, a calcified cartilage (CC) zone, and SCB and STB remodeling regions. Calcified tissue (CC, SCB, and STB) and AC material regions were integrated to form an evolutionary bone-cartilage unit model. Results indicate that with indentation loading, articular cartilage damage occurs at the articular surface. Furthermore, bone remodeling was predicted to occur with a net stiffening of the subchondral bone plate. Changes in indentation force were minimal (<2%) between initial and final peak indentation loading. However, additional degradation and wear of AC and/or alterations in loading may have more pronounced effects on the mechanical response of the bone-cartilage unit. Bone remodeling and articu...Continue Reading

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Mentioned in this Paper

In Silico
Study
Zone
Trabecular Substance of Bone
Abnormal Degeneration
Degenerative Polyarthritis
Surface of Epiphysis
Structure of Articular Cartilage
Nerve Degeneration
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