An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses

Journal of Virology
Kathryn S Carpentier, Adam P Geballe

Abstract

To establish productive infections, viruses must counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate antiviral pathways. The opposing goals of host and viral factors lead to evolutionary arms races that can be illuminated by evolutionary and computational methods and tested in experimental models. Here we illustrate how this perspective has been contributing to our understanding of the interactions of the protein kinase R pathway with large DNA viruses.

References

Nov 11, 1999·Oncogene·B R Williams
May 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·D A LeibH W Virgin
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker
May 24, 2008·The EMBO Journal·Ling-Ling ChenGordon G Carmichael
Dec 2, 2008·Nature Structural & Molecular Biology·Stefan RothenburgKatharina Dittmar
Feb 13, 2009·Journal of Virology·Emily E MarshallAdam P Geballe
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Derek GathererAndrew J Davison
Jan 27, 2012·Journal of Virology·Stephanie J ChildAdam P Geballe
Sep 15, 2012·Nature Reviews. Immunology·Nisha K Duggal, Michael Emerman
Nov 14, 2012·Annual Review of Genetics·Matthew D Daugherty, Harmit S Malik
Nov 28, 2012·Science·Noam Stern-GinossarJonathan S Weissman
Jul 5, 2013·Nature·Javier Prado-MartinezTomas Marques-Bonet
Nov 12, 2013·Journal of Molecular Biology·Rachele CaglianiManuela Sironi
Nov 22, 2013·Journal of Virology·Tina O'GradyErik K Flemington
Jan 4, 2015·Molecular Biology and Evolution·Ross M McBeeSara L Sawyer
Apr 24, 2015·Journal of Virology·Zhilong YangBernard Moss

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Citations

Oct 21, 2015·PLoS Computational Biology·Robin van der LeeMartijn A Huynen
Oct 11, 2019·Trends in Microbiology·Stefan Rothenburg, Greg Brennan

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