An exact maternal-fetal genotype incompatibility (MFG) test

Genetic Epidemiology
S L MinassianJanet S Sinsheimer

Abstract

The maternal-fetal genotype incompatibility (MFG) test can be used for a variety of genetic applications concerning disease risk in offspring including testing for the presence of alleles that act directly through offspring genotypes (child allelic effects), alleles that act through maternal genotypes (maternal allelic effects), or maternal-fetal genotype incompatibilities. The log-linear version of the MFG model divides the genotype data into many cells, where each cell represents one of the possible mother, father, and child genotype combinations. Currently, tests of hypotheses about different allelic effects are accomplished by an asymptotic MFG test, but it is unknown if this is appropriate under conditions that produce small cell counts. In this report, we develop an exact MFG test that is based on the permutation distribution of cell counts. We determine by simulation the type I error and power of both the exact MFG test and the asymptotic MFG test for four different biologically relevant scenarios: a test of child allelic effects in the presence of maternal allelic effects, a test of maternal allelic effects in the presence of child allelic effects, and tests of maternal-fetal genotype incompatibility with and without ch...Continue Reading

References

Jan 1, 1997·Genetic Epidemiology·M A ClevesK B Jacobs
Mar 3, 1999·American Journal of Human Genetics·J C Whittaker, D J Thompson
Mar 26, 1999·American Journal of Human Genetics·C R Weinberg
Jan 13, 2000·American Journal of Human Genetics·D M Umbach, C R Weinberg
May 18, 2000·Statistics in Medicine·V W Berger
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird
Nov 20, 2002·American Journal of Human Genetics·Christina G S PalmerJ Arthur Woodward
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge

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