An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertraline

Human Psychopharmacology
Valérie GuillePradeep J Nathan

Abstract

The underlying effect of serotonergic neurotransmission has been implicated in several psychiatric disorders. The inability to routinely and non-invasively determine the integrity of the serotonergic system in vivo has limited our understanding of disorders with a putative serotonergic abnormality. The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a reliable measure of central serotonin function in humans. While animal studies suggest that the LDAEP is sensitive to changes in central serotonin neurotransmission, evidence in humans has been indirect and inconsistent. The aim of this study was to assess the sensitivity of the LDAEP to acute augmentation in central serotonergic neurotransmission in humans. The study used a double-blind, placebo-controlled cross-over design, in which healthy subjects were tested under four acute treatment conditions, with pharmacologically equivalent single doses of placebo, escitalopram (10 mg), citalopram (20 mg) and sertraline (50 mg) to examine the direct effect of acute enhancement of synaptic serotonin on the LDAEP. Furthermore, the outcome of the serotonergic modulatory effects on the LDAEP was also examined using two methods (dipole source analysis (DSA) ...Continue Reading

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Citations

Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Leon Kenemans, Seppo Kähkönen
Jan 20, 2010·Psychiatry Research·Markus Röhl, Stefan Uppenkamp
Apr 2, 2011·Human Psychopharmacology·Jessica L OlivaPradeep J Nathan
Mar 20, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Natalia JaworskaVerner Knott
Jan 31, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Natalia JaworskaVerner Knott

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