An Examination of Behavioral and Neuronal Effects of Comorbid Traumatic Brain Injury and Alcohol Use

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Andrew R MayerKent E Hutchison

Abstract

Chronic alcohol use disorders (AUDs) and traumatic brain injury (TBI) are highly comorbid and share commonly affected neuronal substrates (i.e., prefrontal cortex, limbic system, and cerebellum). However, no studies have examined how combined physical trauma and heavy drinking affect neurocircuitry relative to heavy drinking alone. The current study investigated whether comorbid AUDs and mild or moderate TBI (AUDs+TBI) would negatively affect maladaptive drinking behaviors (n = 90 AUDs+TBI; n = 62 AUDs) as well as brain structure (i.e., increased atrophy; n = 62 AUDs+TBI; n = 44 AUDs) and function (i.e., activation during gustatory cue reactivity; n = 55 AUDs+TBI; n = 37 AUDs) relative to AUDs alone. Participants reported a much higher incidence of trauma (59.2%) compared with the general population. There were no differences in demographic and clinical measures between groups, suggesting that they were well matched. Although maladaptive drinking behaviors tended to be worse for the AUDs+TBI group, effect sizes were small and not statistically significant. Increased alcohol-cue reactivity was observed in bilateral anterior insula and orbitofrontal cortex, anterior cingulate cortex, medial prefrontal cortex, posterior cingulate ...Continue Reading

References

Dec 1, 1992·Alcoholism, Clinical and Experimental Research·A PfefferbaumE V Sullivan
Jul 3, 1998·The Journal of Head Trauma Rehabilitation·M R HibbardJ Silver
Mar 23, 2001·Journal of Abnormal Psychology·G A Miller, J P Chapman
Jun 30, 2001·The American Journal of Psychiatry·F SchneiderK Zilles
Dec 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hugh MyrickMark S George
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·David A KarekenTing-Kai Li
Dec 14, 2004·NeuroImage·Marcia Levin PelchatJ Daniel Ragland
Oct 28, 2005·Nature Neuroscience·Eric J Nestler
Dec 6, 2005·Clinical Rehabilitation·Sophie EyresAlan Tennant
Sep 14, 2006·Current Opinion in Neurology·Haruki Koike, Gen Sobue
Oct 31, 2006·Trends in Molecular Medicine·Ruben D Baler, Nora D Volkow
Mar 17, 2007·Drug and Alcohol Review·Cheryl J Cherpitel
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesca M FilbeyKent E Hutchison
Aug 25, 2007·Annual Review of Clinical Psychology·Kenneth J SherNatalie A Williams
Sep 5, 2008·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Rael T LangeMichael D Franzen
Feb 11, 2009·Journal of Neurotrauma·James M Bjork, Steven J Grant
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Jul 10, 2010·International Journal of Environmental Research and Public Health·John C M Brust
Dec 31, 2010·Alzheimer Disease and Associated Disorders·Candice PicardOlivier Godefroy
Feb 5, 2011·Biological Psychiatry·Sabine Vollstädt-KleinFalk Kiefer
Jun 17, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric D ClausKent E Hutchison
Jan 1, 2003·Neuropsychological Rehabilitation·Laura A TaylorMichelle A Meade
Oct 13, 2011·British Journal of Clinical Pharmacology·Kanwaljit Chopra, Vinod Tiwari
Mar 22, 2012·Brain Imaging and Behavior·Erin D Bigler, William L Maxwell
May 3, 2012·Brain Imaging and Behavior·Sara B Rosenbaum, Michael L Lipton
Dec 4, 2012·Journal of Studies on Alcohol and Drugs·Eric D ClausKent E Hutchison
Dec 21, 2012·Journal of Neurotrauma·Douglas H SmithJohn T Povlishock
Jan 24, 2013·Journal of Clinical and Experimental Neuropsychology·Jennie PonsfordJohn Taffe
Feb 1, 2013·Brain : a Journal of Neurology·Victoria E JohnsonWilliam Stewart
Feb 26, 2013·Current Opinion in Neurobiology·Jody MayfieldR Adron Harris
Aug 14, 2013·JAMA Internal Medicine·Peter NordströmYngve Gustafson
Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Agnes J JasinskaYavor Yalachkov
May 10, 2014·Annals of Neurology·Peter NordströmAnna Nordström
Jun 27, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Rael T LangeGrant L Iverson
Sep 19, 2014·Neurosurgery·Christopher C Giza, David A Hovda
Oct 12, 2014·Psychopharmacology·Rae A LittlewoodKent E Hutchison
Feb 5, 2015·JAMA Psychiatry·Madeleine GoodkindAmit Etkin
Mar 10, 2015·Molecular and Cellular Neurosciences·Raquel C Gardner, Kristine Yaffe
May 2, 2015·The Journal of Head Trauma Rehabilitation·Gale G WhiteneckJennifer A Bogner
Jul 15, 2015·Journal of Neurotrauma·Zachary M WeilJohn D Corrigan

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Citations

Aug 2, 2019·Brain Imaging and Behavior·James F CavanaghAndrew R Mayer
Dec 2, 2020·Journal of Neurotrauma·Danielle C HergertAndrew R Mayer

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