An examination of neurocognition and symptoms as predictors of post-hospital community tenure in treatment resistant schizophrenia

Psychiatry Research
Anthony O AhmedAdam J Savitz

Abstract

Neurocognition and psychopathology are robust predictors of community functioning and relapse/rehospitalization in schizophrenia. Existing studies are however limited because they have ignored the most chronic, treatment-resistant patients. Moreover, the prediction of functional outcomes has yet to be extended to the duration of community tenure, an indicator of the capacity of chronically-hospitalized patients to gain traction in the community. The current study examined neurocognition and symptom severity at discharge as potential predictors of community tenure in chronically-hospitalized treatment-resistant patients. The study recruited 90 people with treatment-resistant schizophrenia who received services on an inpatient unit. Participants completed measures of psychopathology and neurocognition prior to discharge. Following discharge, participants were tracked at current residences six months and one year post-discharge to assess community tenure. The percentage of individuals who continued to live in the community at 12-month follow-up was 51%. Severe negative symptoms but not neurocognitive impairment or positive symptoms was a significant predictor of shorter post-hospital community tenure. Of the negative symptoms doma...Continue Reading

References

Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·D PerlickJ Teresi
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Mar 1, 1996·The American Journal of Psychiatry·M F Green
Feb 15, 2001·Archives of General Psychiatry·B KirkpatrickW T Carpenter
Dec 18, 2001·Biological Psychiatry·R R Conley, D L Kelly
Mar 29, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Steven M SilversteinAndrew Bloch
Nov 9, 2004·Schizophrenia Research·Michael F GreenRobert K Heaton
Jun 15, 2005·Acta Psychiatrica Scandinavica·J Addington, D Addington
Oct 29, 2005·Schizophrenia Bulletin·Jack J Blanchard, Alex S Cohen
May 2, 2008·Psychological Medicine·P WhittyE O'Callaghan
Jul 12, 2008·IEEE Transactions on Pattern Analysis and Machine Intelligence·Shen-Shyang Ho, Harry Wechsler
Oct 18, 2008·The Kaohsiung Journal of Medical Sciences·Chieh-Hsin LinChing-Hua Lin
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Aidan TurkingtonStephen J Cooper
Jan 6, 2010·Indian Journal of Psychiatry·R K SolankiDeepti Munshi
Feb 1, 2009·Early Intervention in Psychiatry·Sara K LucasAnthony Harris
Jul 27, 2011·Schizophrenia Research·George KonstantakopoulosAntonis M Politis
Mar 2, 2012·Psychiatry Research·Anthony Olufemi AhmedMegan Elizabeth McFarland
Mar 13, 2012·The American Journal of Psychiatry·Gregory P Strauss, James M Gold
Oct 16, 2012·Schizophrenia Research·Gregory P StraussBrian Kirkpatrick
Apr 5, 2013·Acta Psychiatrica Scandinavica·C-H LinC-C Chen
Jan 28, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ann M Kring, Deanna M Barch
Sep 25, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Matti PenttiläJouko Miettunen
Aug 1, 2015·Journal of Psychiatric Research·Anthony O AhmedPeter F Buckley

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Citations

Nov 4, 2016·Perspectives in Psychiatric Care·Yusuke Kurebayashi, Junichi Otaki
May 21, 2019·Frontiers in Psychiatry·Emma Barkus, Johanna C Badcock

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