An examination of sex differences in the effects of early-life opiate and alcohol exposure

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Laurne S TerasakiJaclyn M Schwarz

Abstract

Early-life exposure to drugs and alcohol is one of the most preventable causes of developmental, behavioural and learning disorders in children. Thus a significant amount of basic, animal and human research has focused on understanding the behavioural consequences and the associated neural effects of exposure to drugs and alcohol during early brain development. Despite this, much of the previous research that has been done on this topic has used predominantly male subjects or rodents. While many of the findings from these male-specific studies may ultimately apply to females, the purpose of this review is to highlight the research that has also examined sex as a factor and found striking differences between the sexes in their response to early-life opiate and alcohol exposure. Finally, we will also provide a framework for scientists interested in examining sex as a factor in future experiments that specifically examine the consequences of early-life drug and alcohol exposure.

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Citations

Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret M McCarthy
Nov 7, 2018·American Journal of Speech-language Pathology·Hayo TerbandBen Maassen
Aug 12, 2020·Human Brain Mapping·Andrew SalzwedelWei Gao
Jul 13, 2020·Cell Communication and Signaling : CCS·Carlos G PenalozaZahra Zakeri
Nov 16, 2020·Neurobiology of Disease·Nune DarbinianLaura Goetzl
May 4, 2021·Brain and Behavior·Jaquelinne Pinheiro-da-Silva, Ana Carolina Luchiari
May 5, 2021·Developmental Psychobiology·Kayleigh S J CampbellTim F Oberlander
Jun 29, 2021·Frontiers in Molecular Biosciences·Iskra AraujoDanielle Gulick

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