An examination of the antibiotic effects of cylindrospermopsin on common gram-positive and gram-negative bacteria and the protozoan Naegleria lovaniensis

Environmental Toxicology
J Paul RasmussenChristopher P Saint

Abstract

The importance of the toxin cylindrospermopsin to the function and fitness of the cyanobacteria that produce it remains a matter of conjecture. Given that the structure of cylindrospermopsin has commonalities with other antibacterial protein synthesis inhibitors, such as streptomycin, authors tested the possibility that the toxin might act as an antibacterial compound that can kill competing microbes. Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa were tested by the minimal inhibitory concentration method and significant antibacterial activity was only observed at a cylindrospermopsin concentration of 300 microg mL(-1) after exposure for 5 days. No effect on log phase growth of E. coli was observed for this same toxin concentration. Protein synthesis was inhibited by cylindrospermopsin in E. coli 70S extracts, reduced by 25% compared with controls when treated with 41.5 microg mL(-1) of the toxin; however, a much greater reduction of 97% was observed for chloramphenicol in the same experiment. Naegleria lovaniensis, a phagotrophic protozoan, was more susceptible to cylindrospermopsin, with a decrease in the number of N. lovaniensis plaques after 24-h treatment with 5-50 microg mL(-1) of t...Continue Reading

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Citations

Feb 5, 2013·Environmental Science and Pollution Research International·Mikołaj KokocińskiJanne Soininen
Feb 8, 2011·Applied and Environmental Microbiology·Mete Yilmaz, Edward J Phlips
Oct 24, 2007·Toxicon : Official Journal of the International Society on Toxinology·S M FroscioI R Falconer
Aug 7, 2017·Journal of Complementary & Integrative Medicine·Fatemeh Hosseinpour-JaghdaniMahmoud Rafieian-Kopaei

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