Abstract
The importance of the toxin cylindrospermopsin to the function and fitness of the cyanobacteria that produce it remains a matter of conjecture. Given that the structure of cylindrospermopsin has commonalities with other antibacterial protein synthesis inhibitors, such as streptomycin, authors tested the possibility that the toxin might act as an antibacterial compound that can kill competing microbes. Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa were tested by the minimal inhibitory concentration method and significant antibacterial activity was only observed at a cylindrospermopsin concentration of 300 microg mL(-1) after exposure for 5 days. No effect on log phase growth of E. coli was observed for this same toxin concentration. Protein synthesis was inhibited by cylindrospermopsin in E. coli 70S extracts, reduced by 25% compared with controls when treated with 41.5 microg mL(-1) of the toxin; however, a much greater reduction of 97% was observed for chloramphenicol in the same experiment. Naegleria lovaniensis, a phagotrophic protozoan, was more susceptible to cylindrospermopsin, with a decrease in the number of N. lovaniensis plaques after 24-h treatment with 5-50 microg mL(-1) of t...Continue Reading
References
Jan 1, 1979·Molecular Biology, Biochemistry, and Biophysics·D Vázquez
Nov 1, 1985·Applied and Environmental Microbiology·P R HawkinsI R Falconer
Jan 18, 1995·Biochemical Pharmacology·M T RunnegarS C Lu
Jul 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·K TeraoM Watanabe
Jun 30, 1996·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T KanekoS Tabata
Mar 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·P R HawkinsI R Falconer
Mar 2, 1999·Plant & Cell Physiology·N SatoA Tanaka
Sep 15, 1999·Toxicon : Official Journal of the International Society on Toxinology·M L Saker, G K Eaglesham
Feb 15, 2000·Journal of Bacteriology·E Hoiczyk, A Hansel
Oct 12, 2001·Environmental Toxicology·S M FroscioI R Falconer
Aug 8, 2002·Toxicon : Official Journal of the International Society on Toxinology·J S MetcalfG A Codd
Aug 6, 2003·Environmental Toxicology·Suzanne M FroscioIan R Falconer
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Martin L SakerVitor M Vasconcelos
May 26, 2004·FEMS Microbiology Letters·James S MetcalfGeoffrey A Codd
Sep 8, 2004·Environmental Toxicology·Isabel C G NogueiraVítor M Vasconcelos
Jul 16, 2005·Journal of Toxicology and Environmental Health. Part a·Andrew R HumpageIan R Falconer
Mar 28, 2006·Toxicon : Official Journal of the International Society on Toxinology·S H WhiteG K Eaglesham
Citations
Feb 5, 2013·Environmental Science and Pollution Research International·Mikołaj KokocińskiJanne Soininen
Feb 8, 2011·Applied and Environmental Microbiology·Mete Yilmaz, Edward J Phlips
May 19, 2011·PloS One·Je-Wen LiouHsin-Hou Chang
Jun 29, 2013·Marine Drugs·Aleicia Holland, Susan Kinnear
Apr 23, 2010·Marine Drugs·Susan Kinnear
Mar 19, 2014·Toxins·Victoria RíosAna M Cameán
Apr 1, 2014·Environmental Monitoring and Assessment·Anna Sieroslawska
Oct 24, 2007·Toxicon : Official Journal of the International Society on Toxinology·S M FroscioI R Falconer
Jan 24, 2009·Environmental Toxicology·Valentina MessineoMilena Bruno
Aug 1, 2011·Journal of Phycology·Arnab PramanikJoydeep Mukherjee
Aug 7, 2017·Journal of Complementary & Integrative Medicine·Fatemeh Hosseinpour-JaghdaniMahmoud Rafieian-Kopaei
Jul 2, 2015·Environmental Toxicology and Chemistry·Maranda Esterhuizen-LondtStephan Pflugmacher
Aug 28, 2021·Microorganisms·Azam OmidiMaranda Esterhuizen