An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans

PloS One
Yutao LiuNathan A Kimbrel

Abstract

To examine the association between the 5-HTTLPR polymorphism of the serotonin transporter (SLC6A4) gene, combat exposure, and posttraumatic stress disorder (PTSD) diagnosis and among two samples of combat-exposed veterans. The first sample included 550 non-Hispanic Black (NHB) combat-exposed veterans. The second sample included 555 non-Hispanic White (NHW) combat-exposed veterans. Participants were genotyped for the 5-HTTLPR/rs25531 variants of the SLC6A4 gene. A structured clinical interview was used to diagnose PTSD. Combat and civilian trauma exposure were assessed with validated self-report instruments. Logistic regression was used to test for main effects of 5-HTTLPR on PTSD diagnosis as well as gene x environment (GxE) interactions after adjusting for sex, ancestry proportion scores, civilian trauma exposure, and combat exposure. Within the NHB sample, a significant additive effect was observed for 5-HTTLPR (OR = 1.502, p = .0025), such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. No evidence for an association between 5-HTTLPR and PTSD was observed in the NHW sample. In addition, no evidence for combat x 5-HTTLPR effects were observed in either sample. The present ...Continue Reading

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Citations

Mar 1, 2017·Neuroscience Letters·Sunayana B BanerjeeKerry J Ressler
Jun 7, 2018·Neuropsychobiology·Kaitlin E BountressAnanda B Amstadter
Jun 29, 2017·International Journal of Methods in Psychiatric Research·Mira BrancuJohn A Fairbank
Nov 13, 2018·Frontiers in Psychology·Gianluca EspositoJessica L Borelli
Mar 25, 2017·Frontiers in Molecular Neuroscience·Steffen VogelgesangMarcus Niebert
Oct 13, 2016·Annual Review of Psychology·Thorhildur Halldorsdottir, Elisabeth B Binder

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Methods Mentioned

BETA
PCR

Software Mentioned

smartpca
SAS
GeneMapper
EIGENSOFT

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