An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood.

Personality and Individual Differences
Haroon I SheikhDaniel N Klein

Abstract

Although a vast literature examining the role of attributional styles in depression has accumulated, the origins of such cognitions remain poorly understood. Investigators are increasingly interested in whether cognitive vulnerability to depression is linked to genetic variation. As a preliminary test of this hypothesis, we examined whether the serotonin transporter promoter polymorphism (5-HTTLPR) was associated with attributional styles in children. Thirty-eight children completed a self-report measure of attributional styles, the Child Attributional Style Questionnaire-Revised (CASQ-R). Children were also genotyped for the 5-HTTLPR polymorphism, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR. The short alleles of the 5-HTTLPR and their putative functional equivalents were associated with increased levels of depressogenic attributions for negative events, as measured by the CASQ-R, lending support to the role of 5-HTTLPR polymorphisms in cognitive vulnerability to depression.

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Citations

Jul 12, 2012·Development and Psychopathology·Christopher J PatrickJason S Moser
Aug 28, 2012·Cognition & Emotion·Brandon E GibbJohn E McGeary
May 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cristian BonviciniMassimo Gennarelli
Apr 19, 2011·Behavior Therapy·Mark A WhismanAndrew Smolen
Aug 1, 2015·PloS One·Aurora Szentágotai-TătarAndrei C Miu

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