An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae

Current Microbiology
W S ChampneyKimberly Zurawick

Abstract

Several reports in the literature have described a differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae resistant to erythromycin. Strains of S. pyogenes and S. pneumoniae carrying different erm gene alleles were examined for their susceptibility to the ketolide antibiotics cethromycin (ABT-773) and telithromycin. The effect of the antibiotics on cell growth and viability was assessed as were effects on protein synthesis and 50S ribosomal subunit formation. The susceptibility of wild-type strains of both organisms was compared with effects in strains containing the ermA and ermB methyltransferase genes. A wild-type antibiotic-susceptible strain of S. pyogenes was comparable to an ermA strain of the organism in its ketolide sensitivity, with IC(50) values for 50% inhibition of protein synthesis and 50S ribosomal subunit formation of 10 ng/mL for cethromycin and 16 ng/mL for telithromycin. An S. pneumoniae strain with the ermB gene and an S. pyogenes strain with the ermA gene were also similar in their sensitivity to ketolide inhibition. IC(50) values for inhibition of translation and subunit formation in S. pneumoniae ( ermB) were 30 ng/mL and 55 ng/mL and for th...Continue Reading

Citations

Mar 5, 2009·Microbiology and Molecular Biology Reviews : MMBR·Bruce A Maguire
Apr 21, 2012·International Journal of Microbiology·H C Syed, M Ravaoarinoro
Feb 26, 2010·Pharmacotherapy·Sally RafieCharles L James
Oct 1, 2005·Molecular Microbiology·Stephen DouthwaiteLene Jakobsen
Aug 27, 2005·The Journal of Antimicrobial Chemotherapy·J TamayoUNKNOWN Spanish Group for the Study of Infection in the Primary Health Care Setting
Jan 17, 2020·The Journal of Antimicrobial Chemotherapy·W Scott Champney

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