An Examination of the Frequency of Paravascular Defects and Epiretinal Membranes in Eyes With Early Glaucoma Using En-face Slab OCT Images.

Journal of Glaucoma
Maria A MavrommatisDonald C Hood

Abstract

To examine the frequency of paravascular defects (PDs) and macular epiretinal membranes (ERMs) in eyes categorized as having mild glaucoma or glaucoma suspect using en-face slab analysis of optical coherence tomography (OCT) scans. Fifty-seven glaucomatous eyes, 44 low-risk suspect eyes, and 101 healthy control eyes were included in the study. The 101 glaucomatous and suspect eyes had a mean deviation better than -6 dB on the 24-2 visual field, and a spherical refractive error between±6 D or axial length <26.5 mm. Two OCT-graders masked to eye classification identified ERMs and PDs on en-face slab images of the macula and peripapillary retina using horizontal B-scans and derived vertical B-scans. Glaucomatous eyes had a significantly higher number of PDs and ERMs than healthy controls (PD, P<0.001; ERM, P=0.046) and low-risk glaucoma suspects (PD, P=0.004; ERM, P=0.043). PDs and/or ERMs were present in 16 of 57 (28.1%) glaucomatous eyes, 2 of 44 (4.5%) suspect eyes, and 3 of 101 (3.0%) control eyes. Further, PDs were present in 11 of the 57 (19.3%) glaucomatous eyes, 1 of the 44 (2.3%) suspect eyes and 0 of the 101 (0%) control eyes, ERMs were seen in 7 of the 57 (12.3%) glaucomatous eyes, 1 of the 44 (2.3%) suspects, and 3 of ...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E Chihara, K Chihara
Oct 13, 2005·Archives of Ophthalmology·Keiichi KomeimaYozo Miyake
Dec 13, 2012·Investigative Ophthalmology & Visual Science·Wan Ling WongTien Yin Wong
Jun 19, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Young Hoon HwangYong Ho Sohn
Nov 2, 2014·Retina·Shao-Chong BuLeonoor I Los
Jan 23, 2015·JAMA Ophthalmology·Yuki MuraokaNagahisa Yoshimura
Oct 2, 2015·Investigative Ophthalmology & Visual Science·Donald C HoodToco Y P Chui
Jan 25, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hsin-Yu LiuChung-May Yang
Apr 8, 2016·Investigative Ophthalmology & Visual Science·Donald C HoodBrad Fortune
Apr 21, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yukiko MiyoshiYuki Muraoka
Aug 29, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Florian RüferPhilipp Franko Zeitz
Nov 17, 2016·Translational Vision Science & Technology·Donald C HoodCarlos G De Moraes
Jul 3, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rie OsakaAkitaka Tsujikawa

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Citations

May 9, 2019·Investigative Ophthalmology & Visual Science·Julie BlancCatherine Creuzot-Garcher
Apr 14, 2020·Asia-Pacific Journal of Ophthalmology·Margarita LabkovichRobert Ritch

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