An examination of whether associations exist between maternal and neonatal 25OHD and infant size and adiposity at birth, 6-9 months and 2-2.5 years of age - a longitudinal observational study from the ROLO study

BMC Nutrition
Mary K HoranFionnuala M McAuliffe

Abstract

Vitamin D status in pregnancy and offspring bone health effects are well established, yet limited knowledge exists on the effect of maternal vitamin D status on offspring size/adiposity. This study examines the association of early (13 weeks), late (28 weeks) pregnancy and neonatal (umbilical) 25-hydroxyvitamin D (25OHD) on offspring size/adiposity. This analysis included mother-infant pairs from the ROLO study at birth (n = 292), 6-9 months (n = 160) and 2-2.5 years (n = 287) postpartum. Using Institute of Medicine 2011 Report criteria, 30% of women in early pregnancy and 38% in late pregnancy were at risk of vitamin D deficiency (25OHD < 30 nmol/L). Birthweight was negatively associated with early-pregnancy 25OHD (p = 0.004) and neonatal 25OHD (p < 0.001). Birth length was not associated with 25OHD. Neonatal measures of overall adiposity were negatively associated with neonatal 25OHD (p = 0.001, and p = <0.001 respectively). At 2-2.5 years there was a negative association between weight-for-age z-score and early-pregnancy 25OHD (p < 0.041). Maternal and neonatal 25OHD were negatively associated with offspring size/adiposity at birth and offspring weight-for-age at 2-2.5 years. Results may not reflect a general population repl...Continue Reading

References

Jul 1, 1992·The American Journal of Medicine·M J McKenna
Jan 1, 1985·The American Journal of Clinical Nutrition·M J McKennaF P Muldowney
Apr 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D I Phillips, J B Young
Dec 15, 2005·The Journal of Clinical Endocrinology and Metabolism·Ruth MorleyJohn D Wark
Apr 4, 2006·Obstetrics and Gynecology·Rhona MahonyColm O'Herlihy
Feb 22, 2007·European Journal of Clinical Nutrition·C R GaleUNKNOWN Princess Anne Hospital Study Group
May 7, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T HagenauP Vestergaard
Aug 12, 2008·The American Journal of Clinical Nutrition·Christophers S Kovacs
Nov 21, 2008·Nutrition Reviews·Robyn M LucasRuth Morley
Jan 1, 2009·The Journal of Clinical Endocrinology and Metabolism·Adrian Sayers, Jonathan H Tobias
Feb 9, 2010·The Journal of Clinical Endocrinology and Metabolism·H T ViljakainenC Lamberg-Allardt
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·G D CarterM J Wheeler
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Jan 21, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·R LonerganN Tubridy
Jun 28, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bruce W HollisCarol L Wagner
Apr 20, 2012·The Journal of Nutrition·Lucinda J BlackMairead Kiely
May 23, 2012·Clinical Biochemistry·Kun Zhu, Richard L Prince
May 25, 2012·Calcified Tissue International·Bruce W Hollis, Carol L Wagner
May 25, 2012·The American Journal of Clinical Nutrition·Sarah R CrozierUNKNOWN SWS Study Group
Jun 19, 2012·Thorax·Katharine C PikeUNKNOWN Southampton Women's Survey Study Group
Sep 1, 2012·BMJ : British Medical Journal·Jennifer M WalshFionnuala M McAuliffe
Oct 9, 2012·Fertility and Sterility·Jennifer M WalshFionnuala M McAuliffe
Nov 28, 2012·The British Journal of Nutrition·Roberta A McCarthyEleanor J Molloy
Jun 13, 2013·European Journal of Clinical Nutrition·M van EijsdenT G M Vrijkotte
Dec 18, 2013·The American Journal of Clinical Nutrition·John F AloiaSteven A Abrams
Jan 10, 2014·The American Journal of Clinical Nutrition·Per TornhammarMikael Norman
Jan 24, 2014·European Journal of Endocrinology·Kristin GodangJens Bollerslev
Jan 28, 2014·Clinical Biochemistry·Dana BaileyDaniel E Roth
May 6, 2014·Irish Journal of Medical Science·M HoranF McAuliffe
Sep 6, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E MoralesJ Sunyer
Oct 1, 2014·Annals of Human Biology·Cara L EckhardtLisa M Bodnar
Apr 29, 2015·Early Human Development·Camilla B JensenBerit L Heitmann
Jun 3, 2015·Endocrine Connections·Malachi J McKennaMark T Kilbane

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Methods Mentioned

BETA
protein assay

Clinical Trials Mentioned

ISRCTN54392969

Software Mentioned

ROLO
Gestation
Bulk Calculator
SPSS

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