An Exceedingly Rare Presentation of Severe Folate Deficiency-Induced Non-Immune Hemolytic Anemia

Curēus
Qian ZhangTravis Nace

Abstract

Macrocytic anemia is usually associated with vitamin B12 or folate deficiency. However, folate deficiency was rarely reported as a cause of hemolytic anemia. We present a case of a young man with a history of alcohol abuse who initially presented with an acute on chronic abdominal pain and was found to have jaundice and scleral icterus. His liver enzymes were unremarkable, and his abdominal imaging did not reveal any acute pathology. However, he was found to have a severe non-immune hemolytic anemia secondary to folate deficiency.

References

Sep 24, 1996·Biochemical and Biophysical Research Communications·R OlinescuL Fleischer
Oct 2, 2014·Haematologica·Alberto Zanella, Wilma Barcellini
Jan 31, 2017·Archives of Pathology & Laboratory Medicine·Victoria Parker, Christopher A Tormey
Dec 22, 2017·Journal of General and Family Medicine·Takayo Nagao, Makoto Hirokawa
Mar 5, 2020·Cleveland Clinic Journal of Medicine·Daniel S SochaHeesun J Rogers

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Methods Mentioned

BETA
electrophoresis
flow cytometry

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