An exception within the group of autoimmune blistering diseases: dermatitis herpetiformis, the gluten-sensitive dermopathy

Immunology and Allergy Clinics of North America
Sarolta Karpati

Abstract

Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.

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Citations

Apr 24, 2016·The Journal of Investigative Dermatology·Anna GörögSarolta Kárpáti
Jul 22, 2016·Journal of Dermatological Science·Anna GörögSarolta Kárpáti
Aug 2, 2017·Archives of Pathology & Laboratory Medicine·Daniel R Owen, David A Owen
Mar 15, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H A JuratliM Sárdy

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