An experiment-based model of vein graft remodeling induced by shear stress

Annals of Biomedical Engineering
Roger Tran-Son-TayScott A Berceli

Abstract

Vein graft intimal hyperplasia induced by shear stress is considered to be one of the major causes of vein graft failure. We have developed a mathematical model of vein graft intimal hyperplasia induced by shear stress based on experimental data. Intimal thickness and the rate of intimal thickness change are expressed as functions of shear stress and time. The model coefficients are derived from animal experiments where bilateral rabbit carotid vein grafts are exposed to different shear stress levels. Morphology data of the vein grafts are obtained over multiple time points. The model describes the well-known behavior of intimal thickening, which is inversely related to shear stress. It also depicts the time-dependent behavior of vein graft intimal hyperplasia. Finally, the model is used to simulate the intimal growth around a focal stenosis, which was created by ligating the middle of a vein graft using a suture. Simulation results and experimental data agree qualitatively, and demonstrate that the intima thickens more distal to the stenosed area. These experiments establish the potential of the general experiment-based approach for predicting human vein graft remodeling. Other mechanical and biological factors can be included...Continue Reading

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Citations

Jun 22, 2011·Biomechanics and Modeling in Mechanobiology·Minki HwangRoger Tran-Son-Tay
Aug 16, 2012·Seminars in Dialysis·Ehsan Rajabi-JagahrghRupak K Banerjee
Mar 28, 2013·PloS One·Minki HwangRoger Tran-Son-Tay
Jun 24, 2014·Journal of Vascular Surgery·Kenneth M DeSartScott A Berceli
Jun 5, 2013·International Journal for Numerical Methods in Biomedical Engineering·J VimmrO Bublík
Dec 18, 2013·Journal of Vascular Surgery·Yong HeScott A Berceli
Jul 23, 2013·Journal of Theoretical Biology·Marc Garbey, Scott A Berceli
Jan 28, 2012·Current Opinion in Pharmacology·Anita C Thomas
Feb 24, 2015·Journal of the Mechanical Behavior of Biomedical Materials·J VeselýR Žitný
Jun 7, 2011·The American Journal of Pathology·Peng YuC Keith Ozaki
Sep 1, 2009·Cellular and Molecular Bioengineering·Minki HwangRoger Tran-Son-Tay
Nov 8, 2014·Journal of Biomechanical Engineering·Abhay B RamachandraAlison L Marsden
May 20, 2016·Nature Reviews. Cardiology·Margreet R de VriesPaul H A Quax
May 2, 2017·Frontiers in Physiology·Francesca DonadoniVanessa Díaz-Zuccarini
May 12, 2009·Vascular·Scott A BerceliZhihua Jiang

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