PMID: 37493Apr 1, 1979

An experimental and clinical study of the effect of ketotifen in the treatment of extrinsic bronchial asthma (author's transl)

Praxis und Klinik der Pneumologie
V HartmannJ P Holle

Abstract

The therapeutic value of ketotifen (Zaditen), a new anti-allergic drug, was studied in patients with extrinsic bronchial asthma. a) In 8 persons the protective effect on bronchial provocation tests with allergen was examined 3 and 14 days after treatment and compared with cromoglycate (Intal); b) 19 patients were treated for 6 months with 2 x 1 milligram ketotifen (n = 7), 2 x 2 mg ketotifen (n = 7), 2 x 1 mg clemastine (Tavegil) (n = 5). The results were as follows: a) The amount of inhaled allergen causing a fall of 20% in FEV1.0/VC was 9-12 times larger with both therapeutic regimens. b) Ketotifen definitely improved the asthmatic symptoms as compared with clemastine. The improvement was independent of the dosage. Side-effects occurred more frequently with clemastine. The study confirms the in vitro demonstrated anti-analphylactic properties of ketotifen; that it can be taken by mouth is of particular clinical interest.

Related Concepts

Thiophenes
Vicrom
Zaditen
Bronchial Provocation Tests
Allergens
Piperidines
Allergen (brand of diphenylpyraline)
Antihistamines, Classical
Drug Evaluation
Asthma

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