An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC

Medical Engineering & Physics
Elisabetta TedaldiKeefe B Manning

Abstract

Inferior vena cava (IVC) filters have been used for over five decades as an alternative to anticoagulation therapy in the treatment of venous thromboembolic disease. However, complications associated with IVC filters remain common. Though many studies have investigated blood flow in the IVC, the effects of respiration-induced IVC collapse have not been evaluated. Our hypothesis is that IVC collapse may have an influence on IVC filter performance. Therefore, we herein investigate the hemodynamics in uncollapsed and collapsed IVC configurations using in vitro flow experiments and computational simulations. Particle image velocimetry (PIV) is used to measure the hemodynamics in an idealized, compliant model of the human IVC made of silicone rubber. Flow is studied under uncollapsed and collapsed scenarios, with the minor diameter of the IVC reduced by 30% in the collapsed state. Both rest and exercise flow conditions are investigated, corresponding to suprarenal flow rates of 2 lpm and 5.5 lpm, respectively. Finite element analysis simulations are carried out in a computational model of the undeformed, idealized IVC to reproduce the 30% collapse configuration and an additional 50% collapse configuration. Computational fluid dynami...Continue Reading

Citations

Nov 18, 2018·Cardiovascular Engineering and Technology·Brent A CravenKeefe B Manning
Nov 10, 2018·Cardiovascular Engineering and Technology·Maureen B GallagherKeefe B Manning
Oct 18, 2020·Biomechanics and Modeling in Mechanobiology·Chlöe Harriet ArmourXiao Yun Xu
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Jingying WangChunhian Lee
Nov 30, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Xudong JiangLili Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Hospital Practice
Adarsh Sahni, Vincent Lem
Journal of Vascular Surgery
L J Greenfield, M C Proctor
Journal of Vascular and Interventional Radiology : JVIR
W J MatchettE J Ferris
© 2022 Meta ULC. All rights reserved