Jan 1, 1997

An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration

Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
T PanD Scheidgger


The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.

Mentioned in this Paper

Ventricular Fibrillation
Metoxamine Wellcome
Basic Cardiac Life Support
Adrenergic alpha-Agonists
Electroversion Therapy
Aortic Diseases
Rats, Holtzman
Cardiac Arrest

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