An experimental comparison of electrospray ion-trap and matrix-assisted laser desorption/ionization post-source decay mass spectra for the characterization of small drug molecules

Rapid Communications in Mass Spectrometry : RCM
T LeRicheD A Volmer

Abstract

An experimental comparison of product ion spectra produced by matrix-assisted laser desorption/ionization (MALDI) and electrospray ion-trap MS( n) for a group of small drug molecules is presented in this paper. The goal of the study was to demonstrate the usefulness of MALDI-MS with post-source decay (PSD) and collision-induced dissociation (CID) for the structural analysis of small drug molecules in the drug discovery process, where traditionally electrospray LC/MS methods are used. PSD and PSD/CID gave diverse product ions that were highly indicative of the structure of the drugs investigated (a group of 4-quinolone antibiotics and oleandomycin). In addition, the number of different product ions generated with MALDI-MS was always higher than with electrospray ion-trap MS( n) (with n < or =4) for the drug molecules studied. This investigation also showed that the choice of a suitable MALDI matrix for the analysis of low molecular weight compounds is quite important. It was found that of the three matrices examined, alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) produced the most intense fragmentation levels while TiO2, with its advantage of virtually no low mass background signals, did not generate quite the same amount of in...Continue Reading

References

Jan 11, 2000·Rapid Communications in Mass Spectrometry : RCM·D A Volmer, S Niedziella

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Citations

Sep 19, 2009·Journal of the American Society for Mass Spectrometry·Xiuhua LiDonghao Li
Feb 1, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Nariyasu Mano, Junichi Goto
Apr 13, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hao-Yang WangYin-Long Guo
Apr 15, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Kevin T Fitzgerald, Kristin L Newquist
Oct 15, 2003·Rapid Communications in Mass Spectrometry : RCM·Panos HatsisDietrich A Volmer
Jul 20, 2007·Rapid Communications in Mass Spectrometry : RCM·Gilles FrachePascal Manuelli
Dec 30, 2014·Journal of Pharmaceutical and Biomedical Analysis·Ania Cabrales-RicoLuis Javier González
Aug 28, 2001·Journal of Mass Spectrometry : JMS
Apr 18, 2019·Journal of the American Society for Mass Spectrometry·Andrew R Johnson, Erin E Carlson

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