An experimental feasibility study on the use of scattering foil free beams for modulated electron radiotherapy

Physics in Medicine and Biology
T ConnellJan Seuntjens

Abstract

The potential benefit of using scattering foil free beams for delivery of modulated electron radiotherapy is investigated in this work. Removal of the scattering foil from the beamline showed a measured bremsstrahlung tail dose reduction just beyond R(p) by a factor of 12.2, 6.9, 7.4, 7.4 and 8.3 for 6, 9, 12, 16 and 20 MeV beams respectively for 2 × 2 cm(2) fields defined on-axis when compared to the clinical beamline. Monte Carlo simulations were matched to measured data through careful tuning of source parameters and the modification of certain accelerator components beyond the manufacturer's specifications. An accelerator model based on the clinical beamline and one with the scattering foil removed were imported into a Monte Carlo-based treatment planning system (McGill Monte Carlo Treatment Planning). A treatment planning study was conducted on a test phantom consisting of a PTV and two distal organs at risk (OAR) by comparing a plan using the clinical beamline to a plan using a scattering foil free beamline. A DVH comparison revealed that for quasi-identical target coverage, the volume of each OAR receiving a given dose was reduced, thus reducing the dose deposited in healthy tissue.

References

May 1, 1995·Medical Physics·D W RogersT R Mackie
Oct 27, 1999·Medical Physics·M G KarlssonC M Ma
Aug 25, 2000·Physics in Medicine and Biology·C M MaA L Boyer
Apr 9, 2004·Medical Physics·Kenneth R HogstromJulian G Rosenman
Mar 31, 2005·Physics in Medicine and Biology·E C Schreiber, B A Faddegon
Apr 6, 2006·Physics in Medicine and Biology·F C P du PlessisC-M Ma
Nov 18, 2006·Physics in Medicine and Biology·T GauerR Schmidt
Jun 9, 2007·Medical Physics·Lilie L W Wang, David W O Rogers
Aug 1, 2007·Physics in Medicine and Biology·A AlexanderJ Seuntjens
Feb 26, 2008·Physics in Medicine and Biology·Eric E KleinRobert E Drzymala
Feb 26, 2008·Physics in Medicine and Biology·Bruce A FaddegonMakoto Asai
Dec 23, 2008·Physics in Medicine and Biology·Eric E KleinDaniel A Low
Nov 19, 2009·Physics in Medicine and Biology·T VatanenT Lahtinen
Feb 24, 2010·Medical Physics·Tanner Connell, James L Robar
Jan 19, 2011·Physics in Medicine and Biology·Josip MihaljevicMarkus Alber

❮ Previous
Next ❯

Citations

May 3, 2013·Medical Physics·Pavlos Papaconstadopoulos, Jan Seuntjens
Jun 1, 2014·Medical Physics·T ConnellJ Seuntjens
Sep 2, 2016·Radiation Oncology·Jong In ParkSung-Joon Ye
Sep 11, 2014·Journal of Applied Clinical Medical Physics·Shiqin SuJames L Robar
May 14, 2017·Medical Physics·Marc-André RenaudJan Seuntjens
Feb 4, 2014·Physics in Medicine and Biology·Ahmed EldibC-M Charlie Ma
Apr 20, 2014·Physics in Medicine and Biology·T Connell, J Seuntjens
Dec 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Reza MaskaniJafar Fatahiasl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
S Guru PrasadW D Bloomer
© 2021 Meta ULC. All rights reserved