An experimental model-based exploration of cytokines in ablative radiation-induced lung injury in vivo and in vitro

Lung
Zhen-Yu HongMichael D Story

Abstract

Stereotactic ablative radiotherapy is a newly emerging radiotherapy treatment method that, compared with conventionally fractionated radiation therapy (CFRT), allows an ablative dose of radiation to be delivered to a confined area around a tumor. The aim of the present study was to investigate the changes of various cytokines that may be involved in ablative radiation-induced lung injury in vitro and in vivo. In the in vivo study, ablative-dose radiation was delivered to a small volume of the left lung of C3H/HeJCr mice using a small-animal irradiator. The levels of 24 cytokines in the peripheral blood were tested at several time points after irradiation. For the in vitro study, three mouse cell types (type II pneumocytes, alveolar macrophages, and fibroblasts) known to play important roles in radiation-induced pneumonitis and lung fibrosis were analyzed using a co-culture system. In the in vivo study, we found obvious patterns of serum cytokine changes depending on the volume of tissue irradiated (2-mm vs. 3.5-mm collimator). Only the levels of 3 cytokines increased with the 2-mm collimator at the acute phase (1-2 weeks after irradiation), while the majority of cytokines were elevated with the 3.5-mm collimator. In the in vitr...Continue Reading

References

Jun 1, 1978·The American Journal of Surgical Pathology·L F Fajardo, M Berthrong
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P RubinJ N Finkelstein
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR L Jirtle
Feb 7, 2001·International Journal of Radiation Biology·W WestermannK H Frank
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M P KeaneR M Strieter
Jan 11, 2002·Experimental and Molecular Pathology·Hideo SakamotoRichard Kradin
Mar 28, 2002·Seminars in Radiation Oncology·Yuhchyau ChenPaul Okunieff
Jul 9, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Claudia E RübeChristian Rübe
Aug 3, 2004·The Journal of Clinical Investigation·Roderick J PhillipsRobert M Strieter
Mar 4, 2005·The American Journal of Pathology·Bethany B MooreGalen B Toews
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Vivek Mehta
Dec 22, 2005·American Journal of Physiology. Renal Physiology·Roshni R MollsHamid Rabb
Apr 15, 2006·The Cancer Journal·Robert D Timmerman, Michael Story
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Mar 31, 2007·Seminars in Radiation Oncology·Katharina FleckensteinZeljko Vujaskovic
Mar 12, 2008·Journal of Leukocyte Biology·Diane D ShaoDarrell Pilling
Mar 23, 2010·Experimental Hematology·Erica L Herzog, Richard Bucala
Nov 18, 2010·Physics in Medicine and Biology·K H SongT D Solberg
Dec 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lei SunThomas P Shanley
Mar 30, 2011·Physics in Medicine and Biology·R PidikitiT D Solberg
May 18, 2011·International Journal of Radiation Biology·Carl J JohnstonJacqueline P Williams

❮ Previous
Next ❯

Citations

Dec 22, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M TrovoU Ricardi
Jan 4, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D SchlesingerJ-F Aubry
Sep 1, 2018·Journal of Radiation Research·Anna LierovaZuzana Sinkorova
Mar 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simone de LeveVerena Jendrossek
Oct 19, 2019·Cancers·Simone de LeveVerena Jendrossek
Oct 31, 2019·Expert Review of Anticancer Therapy·Michael T MilanoFeng-Ming Spring Kong
Dec 16, 2016·Physics in Medicine and Biology·E FordN Mayr
May 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jee-Youn KimYun-Sil Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
T HerrmannA Knorr
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
W C Zheng
© 2022 Meta ULC. All rights reserved