PMID: 9428935Jan 16, 1998Paper

An experimental model for infiltration of malignant lymphoma to the eye and brain

Virchows Archiv : an International Journal of Pathology
N AssafJacob Hochman

Abstract

Currently there is no adequate experimental model available whereby the lethal infiltration of malignant lymphoma to the eye and CNS can be studied. Variant S49 mouse lymphoma cells that exhibit cell-cell adhesion properties (named Rev-2-T-6) were inoculated intraperitoneally into Balb/C mice at the ages of 6-60 days postnatal. Mice inoculated between days 6-11 postnatal developed signs of eye and CNS involvement with an apparent peak (58% of mice) at day 7. None of the mice inoculated beyond day 11 exhibited such signs. Histological analysis of these sites revealed tumorous infiltrates into a variety of structures in the orbit, intraocular tissues, along the optic nerve and in the brain. Additional analysis of the histopathological data, based on the structures demonstrating the highest frequency of lymphoma infiltration, suggests preferred routes of lymphoma entry to the brain and eye. Thus, entry to the brain can occur mainly through the choroid plexus and cranial nerves or cranial nerve ganglia. Entry to the eye may occur from the brain (along the optic nerve), and through hematogenous infiltration of orbital structures. No data were found that would support retrograde infiltration of the lymphoma from the eye to the brain....Continue Reading

Citations

Aug 7, 2012·Clinical & Experimental Metastasis·Jacob HochmanChi-Chao Chan
Mar 29, 2002·Survey of Ophthalmology·Russell W ReadNarsing A Rao
Dec 1, 2006·Neurosurgical Focus·Kristoph JahnkeEdward A Neuwelt
Oct 22, 2016·British Journal of Haematology·Liron Frishman-Levy, Shai Izraeli
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrés J M FerreriTracy Batchelor
Jul 1, 2007·Retinal Cases & Brief Reports·Yukihiro HorieShigeaki Ohno
Mar 9, 2019·Current Hematologic Malignancy Reports·Jordan N Noble, Anjali Mishra
Oct 11, 2014·Journal of Neuro-oncology·Rym Ben Abdelwahed BaggaSylvain Fisson
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carole SoussainEdward A Neuwelt

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