An experimental model of allergic asthma in cats sensitized to house dust mite or bermuda grass allergen

International Archives of Allergy and Immunology
Carol R Norris ReineroLaurel J Gershwin

Abstract

Animal models are used to mimic human asthma, however, not all models replicate the major characteristics of the human disease. Spontaneous development of asthma with hallmark features similar to humans has been documented to occur with relative frequency in only one animal species, the cat. We hypothesized that we could develop an experimental model of feline asthma using clinically relevant aeroallergens identified from cases of naturally developing feline asthma, and characterize immunologic, physiologic, and pathologic changes over 1 year. House dust mite (HDMA) and Bermuda grass (BGA) allergen were selected by screening 10 privately owned pet cats with spontaneous asthma using a serum allergen-specific IgE ELISA. Parenteral sensitization and aerosol challenges were used to replicate the naturally developing disease in research cats. The asthmatic phenotype was characterized using intradermal skin testing, serum allergen-specific IgE ELISA, serum and bronchoalveolar lavage fluid (BALF) IgG and IgA ELISAs, airway hyperresponsiveness testing, BALF cytology, cytokine profiles using TaqMan PCR, and histopathologic evaluation. Sensitization with HDMA or BGA in cats led to allergen-specific IgE production, allergen-specific serum...Continue Reading

Citations

Mar 4, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Amy E DeClueCarol R Reinero
Aug 4, 2009·Journal of Feline Medicine and Surgery·Leah A CohnCarol R Reinero
Aug 31, 2010·Journal of Feline Medicine and Surgery·Christine M Venema, Coretta C Patterson
Nov 27, 2010·Journal of Feline Medicine and Surgery·Cherlene DelgadoCarol R Reinero
Dec 15, 2010·Journal of Feline Medicine and Surgery·Carol R ReineroVamsi P Guntur
Dec 31, 2010·Journal of Feline Medicine and Surgery·Laura A NafeCarol R Reinero
Jun 7, 2011·Journal of Feline Medicine and Surgery·Christine G CocayneAmy E DeClue
Feb 15, 2011·Journal of Veterinary Internal Medicine·L R Johnson, W Vernau
Nov 28, 2012·International Archives of Allergy and Immunology·Christine M VenemaStephan A Carey
Nov 3, 2007·American Journal of Veterinary Research·Elizabeth K SchooleyCarol R Reinero
Mar 19, 2014·Veterinary Immunology and Immunopathology·Shanna L SealsCherie M Pucheu-Haston
Nov 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Julie E Trzil, Carol R Reinero
Jun 23, 2015·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Isabelle MasseauCarol Reinero
Oct 11, 2011·Veterinary Immunology and Immunopathology·Chee-Hoon ChangCarol R Reinero
Mar 4, 2011·The Veterinary Journal·Nathalie Kirschvink, Jérôme Leemans
Oct 12, 2010·The Veterinary Clinics of North America. Small Animal Practice·Julia K Veir, Michael R Lappin
Mar 3, 2010·Veterinary Parasitology·Patricia DingmanRodrigo Morchon
Oct 16, 2015·The Journal of Pathology·Kurt Williams, Jesse Roman
Oct 13, 2009·Veterinary Immunology and Immunopathology·Tekla M Lee-FowlerCarol R Reinero
Oct 13, 2009·Veterinary Immunology and Immunopathology·Carol R Reinero
Jul 7, 2009·Veterinary Immunology and Immunopathology·Jason M EberhardtCarol R Reinero
Apr 28, 2009·Pulmonary Pharmacology & Therapeutics·Judith E AllenTara E Sutherland
Nov 6, 2007·Veterinary Immunology and Immunopathology·Carol R ReineroAmy E DeClue
Aug 19, 2007·The Veterinary Clinics of North America. Small Animal Practice·Leah A Cohn, Carol R Reinero
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·A Bähr, E Wolf
Jun 12, 2013·Journal of Veterinary Internal Medicine·C R SharpC R Reinero
Mar 21, 2016·Journal of Veterinary Internal Medicine·M Grobman, C Reinero
Dec 6, 2005·Veterinary Immunology and Immunopathology·Carol R ReineroLaurel J Gershwin
Sep 16, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J E TrzilC R Reinero
Jun 3, 2015·Biochemical Pharmacology·Chantal CossetteWilliam S Powell
Mar 14, 2009·Environmental Research·Carol R ReineroPeter Rabinowitz
Feb 7, 2017·The Journal of Veterinary Medical Science·Sungjun WonJunghee Yoon
Dec 21, 2014·Journal of Feline Medicine and Surgery·Laura A Nafe, Stacey B Leach
Nov 2, 2014·Journal of Feline Medicine and Surgery·Megan E GrobmanCarol R Reinero
Feb 9, 2013·Journal of Feline Medicine and Surgery·Laura A NafeCarol R Reinero

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