An experimental model of chronic renal allograft rejection in the rat using triple drug immunosuppression

Transplantation
A SootsJ Ahonen

Abstract

Chronic rejection is a major problem in renal transplantation. Various experimental models have been developed to study vasculopathy of chronic rejection. However, animal models resembling the clinical situation of renal transplantation with combination therapy of basic immunosuppression are not available. The aim of this study was to find an experimental model of a donor-recipient rat strain combination that, under triple drug immunosuppressive treatment (methylprednisolone, cyclosporine, and azathioprine), would develop chronic rejection within a few weeks. Renal transplantations were performed in strain combinations of DA-->AO, PVG-->BN, and DA-->BN. In each group, 5-8 animals received triple drug treatment of methylprednisolone (2 mg/kg), azathioprine (2 mg/kg), and cyclosporine (5 mg/kg) daily, 5-10 animals were left without treatment, and 6 syngenic transplantations were performed. The grafts were monitored with ultrasound-guided fine needle aspiration biopsies to quantify the inflammation in the graft. Graft histology was performed in parallel and quantified by using the chronic allograft damage index (CADI). In nonimmunosuppressed animals, irreversible acute rejection with a high peak of inflammation appeared in every s...Continue Reading

References

Jan 1, 1992·Kidney International·H M IsoniemiP Häyry
Sep 1, 1991·Transplantation·N L TilneyD H Adams
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A MennanderP Häyry
Nov 1, 1969·Transplantation·E WhiteY Mullen
Jul 1, 1984·Transplantation·P Häyry, E von Willebrand
Nov 1, 1994·Clinical Nurse Specialist CNS·C Neisser-Frankson
Nov 1, 1994·The Journal of Clinical Investigation·H S MackenzieN L Tilney
Dec 1, 1994·Transplantation Proceedings·P Häyry, S Yilmaz
Aug 1, 1993·Immunological Reviews·P HäyryE Taskinen

❮ Previous
Next ❯

Citations

Sep 21, 2000·Folia Microbiologica·P Rossmann, J Lácha
Mar 27, 2001·Transplantation Proceedings·L KrogerusI Lautenschlager
Mar 20, 2003·Transplantation Proceedings·L KrogerusI Lautenschlager
Mar 20, 1999·Transplantation Proceedings·K InkinenI Lautenschlager
Mar 18, 2003·Transplantation·Paul F GoresRay V Rajotte
Aug 19, 2003·Transplantation·Jose R TorrealbaStuart J Knechtle
Dec 21, 2011·The Journal of Trauma·Timothy P PlackettDemetrios Demetriades
Aug 26, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·H KauppinenI Lautenschlager
May 25, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaija InkinenIrmeli Lautenschlager
Apr 12, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaija A InkinenJuhani P Ahonen
Jul 27, 2004·Microsurgery·Alexander PietschDebra A Hullett
Apr 6, 2005·Transplantation Proceedings·A P PietschD A Hullett
Jun 21, 2005·Transplantation Proceedings·L H GaoW J Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.