PMID: 18199401Jan 18, 2008Paper

An experimental study of a rat model with MODS as a result of trauma induced infection

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Yu BanTan-shi Li

Abstract

To reproduce an animal model of multiple organ dysfunction syndrome (MODS) which was caused by two "hits" (injury and infection), to explore the potential aetiology and strategies of treatment. The rats' extremities were crushed, resulting in severe injury with multiple closed fractures and extensive contusion of soft tissues. After 12 hours, a thirty percent total body surface area III (TBSA III) burns contaminated by Pseudomonas aeruginosa was inflicted upon the injury rats in MODS group. Rats'activities and wound appearance were observed, body weight, temperature, heart rate were recorded, and the blood lipopolysaccharide (LPS) level, the functional changes in all major organs, the occurrence rate of inflammatory reactions, the mortality of MODS and morbidity, and the pathological changes of the major organs were monitored at 24, 48, 96, 120 hours. To compare with pre-injury states and control group there were marked increases in alanine aminotransferase (ALT), total bilirubin (TBil), blood urea nitrogen (BUN), creatinine (Cr), aspartate aminotransferase (AST), creatine phosphokinase (CPK) contents 48 hours after the injuries (all P<0.05). When compared with the control group, there was significant difference (P<0.05). After...Continue Reading

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