PMID: 22587928May 17, 2012Paper

An experimental study of contrast enhanced ultrasound diagnosis of cerebral intraparenchymal hemorrhage in dogs

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Xuan ZhouTan-Shi Li

Abstract

To explore the role of contrast enhanced ultrasound (CEUS) in diagnosing experimental cerebral intraparenchymal hemorrhage (IH) in dogs. A self-control study was conducted. An IH model was reproduced by puncturing middle cerebral artery (MCA) in 12 dogs. Two-dimensional ultrasound and CEUS were conducted immediately, 30 minutes, and 1 hour after modeling, respectively, to observe the lesion echo and bleeding area. CT scans were also conducted at 1 hour after modeling, then the lesion size in CT scan was compared with that of CEUS. In 12 dogs IH model was reproduced successfully, and unilateral hematomas were confirmed by CT and pathological examination. Two-dimensional ultrasound of IH showed irregular high-echo area, with unclear boundary, but it was not able to show active bleeding. CEUS demonstrated active bleeding by outflow and pooling of contrast agent with obvious enhancement. CEUS of the hematoma showed perfusion deficit, with a clear boundary. The size of bleeding lesions (cm) continued to increase at 30 minutes and 1 hour after modeling (1.47±0.40, 1.76±0.45 by CEUS measuring), and demonstrated statistically significant difference comparing with the measurement of IH immediately after modeling (1.03±0.24, both P<0.01)...Continue Reading

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