An experimental study of exenatide effects on renal injury in diabetic rats1

Acta Cirúrgica Brasileira
Xiaodong WangDongfang Bai

Abstract

To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Then, the later 3 groups were treated with 2, 4 and 8 μg/kg exenatide for 8 weeks, respectively. The serum and urine biochemical indexes and oxidative stress and inflammatory indexes in renal tissue were determined. Compared to the model group, in exenatide-3 group the serum fasting plasma glucose and hemoglobin A1c levels were significantly decreased, the fasting insulin level was significantly increased, the renal index and blood urea nitrogen, serum creatinine and 24 h urine protein levels were significantly decreased, the renal tissue superoxide dismutase and glutathione peroxidase levels were significantly increased, the malondialdehyde level was significantly decreased, and the renal tissue tumor necrosis factor alpha, interleukin 6, hypersensitive C-reactive protein and chemokine (C-C motif) ligand 5 levels were significantly decreased P<0.05). Exenatide can mitigate the renal injury in diabetic rats. The mechanisms may be rela...Continue Reading

References

May 2, 2001·Digestive Diseases and Sciences·C Y ChenX Z Lin
Jan 12, 2002·Kidney International·Maristela Lika OnozatoChristopher S Wilcox
Dec 24, 2004·Diabetes Care·Jorge L GrossThemis Zelmanovitz
Nov 12, 2005·European Journal of Clinical Investigation·E Ritz, V Haxsen
Jan 6, 2006·Journal of the American Society of Nephrology : JASN·Elena Galkina, Klaus Ley
Mar 29, 2008·Metabolic Syndrome and Related Disorders·M A Charles, J L Selam
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·A M S Brooks, C A Lissett
Jul 6, 2010·Free Radical Biology & Medicine·Steen V PetersenJan J Enghild
Oct 14, 2010·Current Medicinal Chemistry·N KashiharaY S Kanwar
Dec 24, 2011·Journal of Ethnopharmacology·Qiao-feng WuChen-huan Yu

❮ Previous
Next ❯

Citations

Jul 23, 2020·Frontiers in Pharmacology·Daiji Kawanami, Yuichi Takashi
Oct 8, 2020·Current Opinion in Pharmacology·Martina VitaleGiuseppe Pugliese
Sep 3, 2021·BioMed Research International·Habib YaribeygiAmirhossein Sahebkar

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme linked immunosorbent assay
enzyme-linked immunosorbent assays
MDA

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved