An Experimental Study of Histopathologic Effects of Hemostatic Agents Used in Spinal Surgery

World Neurosurgery
Idiris Altun

Abstract

To evaluate and compare the histopathologic effects of various hemostatic agents used in spinal surgery on an experimental laminectomy model in rats. There were 110 rats randomly allocated into 11 groups, including sham, control, AnkaferdBlood Stopper (herbal hemostatic), SeraSeal (agar and bovine factor proteins), FLOSEAL (gelatin granules and thrombin), SURGIFLO (gelatin paste), HELITENE (absorbable collagen), Beriplast (fibrin sealant containing fibrinogen, factor XIII, and thrombin), TISSEEL (fibrin sealant), BLOODCARE (hemostatic powder), and SURGICEL (oxidized cellulose polymer) groups. Hemostatic agents were applied on the epidural region after laminectomy was performed until the identification of dura mater and nerve root. After a follow-up period of 12 weeks, rats were sacrificed, and histologic sections were performed proximal and distal to laminectomy zone. Groups were histopathologically compared in terms of chronic inflammation, fibrosis, and vascularization. There was no difference between groups in terms of acute inflammation (P = 0.159). Chronic inflammation was more remarkable in the herbal hemostatic group (P = 0.036), and there was severe fibrosis in absorbable collagen hemostatic, fibrin sealant, and powder ...Continue Reading

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Citations

Sep 16, 2018·Acta orthopaedica et traumatologica turcica·Esra DemirelBetül Gündoğdu
Aug 1, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Ahmed Musaad Abd El-FattahAli Tawfik
Sep 14, 2018·World Journal of Clinical Cases·Osman TanriverdiMetehan Eseoglu
Nov 5, 2021·Neurosurgical Review·C SchonauerE Tessitore

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