An experimental study of the elastic properties of the human Bruch's membrane-choroid complex: relevance to ageing.

The British Journal of Ophthalmology
M UgarteJ Marshall

Abstract

To investigate the mechanical properties (stress-strain relation, elasticity, hysteresis, response to stress spikes and drops) of isolated human Bruch's membrane-choroid, as well as the effect of ageing and aged related macular degeneration (AMD). 13 Bruch's membrane-choroid complexes were obtained from human donors (21-97 years). Two samples (aged 85 and 95) showed signs of AMD including large, soft drusen, choroidal neovascularisation, and/or disciform scars. Various hydrostatic pressures (stress) were applied to the choroidal surface of mid-peripheral samples mounted in a modified open Ussing chamber. Linear scans of the tissue were recorded by optical coherence tomography (OCT) and the pressure induced deformation (strain), elasticity, hysteresis, and response to pressure spikes and drops measured. The elasticity of human Bruch's membrane-choroid complex decreased linearly with ageing (p<0.001) after the age of 21 with an approximate reduction of 1% per year. The decrease was not exaggerated in AMD. The recoil capacity of Bruch's membrane-choroid was not affected by ageing. The response to pressure spikes/drops was similar in age matched normal and AMD eyes. The results suggest that although the aged induced decrease in Bru...Continue Reading

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Citations

Jun 5, 2012·Tissue Engineering. Part C, Methods·V Timothy NayarAndrea M Hodge
Feb 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jena J SteinleLisa S McFayden-Ketchum
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Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Maedeh KhodamoradiReza Zarei
Sep 30, 2021·Clinical & Experimental Ophthalmology·Min ZhangYongxiang Jiang
Nov 9, 2011·Experimental Eye Research·Zdravka CankovaMark Johnson

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