PMID: 7580747Jul 1, 1995Paper

An experimental study of the pharmacological activity of opiate receptor ligands on models of adrenaline-induced arrhythmias

Eksperimental'naia i klinicheskaia farmakologiia
Iu B LishmanovD S Ugdyzhekova

Abstract

The influence of intracerebroventricular injection of opioid peptides on the incidence and severity of ventricular arrhythmia induced by intravenous administration of epinephrine was studied. It was found that DAGO, a selective mu-agonist, and DADLE, a nonselective delta-agonist, reduce the incidence and severity of cardiac arrhythmia in rats. On the contrary, DSLET, a selective delta-agonist, and Dynorphin A 1-13 (kappa-agonist), potentiates epinephrine-induced arrhythmias. beta-Endorphin do not affect the arrhythmia. The activation of cerebral mu-opioid receptors is shown to prevent the appearance of arrhythmia. On the contrary, the activation of delta- and kappa-receptors induces the appearance of arrhythmia.

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