An experimental study on prednisolone-induced interstitial pneumonia caused by Pneumocystis carinii

Kisaengch'unghak chapchi. The Korean journal of parasitology
D W ShinY E Na

Abstract

This study was performed to observe the role of Pneumocystis carinii as an etiologic agent of interstitial pneumonia in immunocompromised hosts. Total 90 male Sprague-Dawley rats, approximately 150-180 g, were used. Fifteen of them were used as control group and remaining 75 (5 groups) were as immunosuppression groups; group 1 received prednisolone (25 mg/kg twice weekly) only; group 2 prednisolone and tetracycline (75 mk/kg/day); group 3 prednisolone, tetracycline and trimethoprim-sulfamethoxazole (50-250 mg/kg/day); group 4 prednisolone and trimethoprimsulfamethoxazole; and group 5 prednisolone and griseofulvin (300 mg/kg/day) until death. The survival days of each group rat were calculated, and upon death their lungs were removed immediately and then stamp smears were prepared and stained by Giemsa or toluidine blue O. For histopathologic observation, lungs were fixed in 10% formalin, cut into sections and stained with Gomori's methenamine silver, hematoxylin-eosin, and Brown & Brenn stain. The results obtained were as follows: 1. The mean survival time of each group rat was 19.3 +/- 5.2 days (group 1), 41.1 +/- 14.0 days (group 2), 50.5 +/- 18.4 days (group 3), 43.0 +/- 22.9 days (group 4) or 21.8 +/- 5.1 days (group 5). Si...Continue Reading

References

Sep 1, 1975·CRC Critical Reviews in Clinical Laboratory Sciences·W T Hughes
Jun 1, 1984·European Journal of Clinical Microbiology·L L Pifer
Aug 1, 1983·Antimicrobial Agents and Chemotherapy·W T Hughes, B L Smith
Jul 1, 1959·The Journal of Experimental Medicine·W H SHELDON

❮ Previous
Next ❯

Citations

Aug 12, 2009·Journal of Developmental and Behavioral Pediatrics : JDBP·Subhadra EvansLonnie K Zeltzer
Sep 1, 1992·Kisaengch'unghak chapchi. The Korean journal of parasitology·D W ShinK J Yun
Aug 2, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·Lisa MacintyreMichelle Rae
Jan 21, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Marco PaoloniValter Santilli
Aug 19, 2009·American Journal of Clinical Oncology·Christopher S PlattaJames S Welsh
May 7, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Martin T SteinMichael J Hennessy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.