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An experimentally determined evolutionary model dramatically improves phylogenetic fit

bioRxiv

Feb 20, 2014

Jesse D Bloom

Abstract

All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models do not realistically represent the site-heterogeneous selection that governs actual sequence change. Attempts to remedy this problem have invol...read more

Mentioned in this Paper

Site
Influenza
Influenza virus vaccine
Phylogenetic Analysis
Nucleoproteins
High-Throughput RNA Sequencing
Deep Sequencing
Mutagenesis Procedure
Mutagenesis Process
Analysis
20
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Paper Details
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An experimentally determined evolutionary model dramatically improves phylogenetic fit

bioRxiv

Feb 20, 2014

Jesse D Bloom

PMID: 990002899

DOI: 10.1101/002899

Abstract

All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models do not realistically represent the site-heterogeneous selection that governs actual sequence change. Attempts to remedy this problem have invol...read more

Mentioned in this Paper

Site
Influenza
Influenza virus vaccine
Phylogenetic Analysis
Nucleoproteins
High-Throughput RNA Sequencing
Deep Sequencing
Mutagenesis Procedure
Mutagenesis Process
Analysis
20
1
8
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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