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An experimentally determined evolutionary model dramatically improves phylogenetic fit

bioRxiv

Feb 20, 2014

Jesse D. Bloom

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Abstract

All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models do not realistically represent the site-heterogeneous selection that governs actual sequence change. Attempts to remedy this problem have invol...read more

Mentioned in this Paper

Mutagenesis Process
Influenza virus vaccine
Determination Aspects
Site
High-Throughput RNA Sequencing
Genes
Mutagenesis Procedure
Analysis
Influenza
Phylogenetic Analysis
20
1
8
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  • An experimentally determined evolutionary model dramatically improves phylogenetic fit

    bioRxiv

    Feb 20, 2014

    Jesse D. Bloom

    PMID: 990002899

    DOI: 10.1101/002899

    Abstract

    All modern approaches to molecular phylogenetics require a quantitative model for how genes evolve. Unfortunately, existing evolutionary models do not realistically represent the site-heterogeneous selection that governs actual sequence change. Attempts to remedy this problem have invol...read more

    Mentioned in this Paper

    Mutagenesis Process
    Influenza virus vaccine
    Determination Aspects
    Site
    High-Throughput RNA Sequencing
    20
    1
    8

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