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An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologs

bioRxiv

Apr 3, 2014

Jesse D. Bloom

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Abstract

Phylogenetic analyses of molecular data require a quantitative model for how sequences evolve. Traditionally, the details of the site-specific selection that governs sequence evolution are not known a priori , making it challenging to create evolutionary models that adequately capture t...read more

Mentioned in this Paper

Beta-Lactamase
Mutation Abnormality
Influenza virus vaccine
Beta-lactamase TEM-1
Lactamase
Gene Function
Influenza
Nucleoproteins
3
2
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  • An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologs

    bioRxiv

    Apr 3, 2014

    Jesse D. Bloom

    PMID: 990003848

    DOI: 10.1101/003848

    Abstract

    Phylogenetic analyses of molecular data require a quantitative model for how sequences evolve. Traditionally, the details of the site-specific selection that governs sequence evolution are not known a priori , making it challenging to create evolutionary models that adequately capture t...read more

    Mentioned in this Paper

    Beta-Lactamase
    Mutation Abnormality
    Influenza virus vaccine
    Beta-lactamase TEM-1
    Lactamase
    3
    2

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