An expert opinion on PANDAS/PANS: highlights and controversies

International Journal of Psychiatry in Clinical Practice
Francesca ChiarelloStefano Pallanti

Abstract

'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections' (PANDAS) identified a unique subgroup of patients with abrupt onset of obsessive compulsive disorder (OCD) symptoms clinically related to Streptococcus infection and accompanied by neuropsychological and motor symptoms. After almost 20 years, PANDAS has not been accepted as distinct disorder and new criteria for paediatric acute-onset neuropsychiatric syndrome (PANS) have been replaced it, highlighting the fact that several agents rather than only Streptococcus might be involved. Extensive review of the PANDAS/PANS literature was performed on PubMed. Although antibiotics have been reported to be effective for acute and prophylactic phases in several uncontrolled studies and non-steroidal anti-inflammatory drugs (NSAID) are used during exacerbations, clinical multicenter trials are still missing. Selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioural therapy (CBT) are still the first line of recommendation for acute onset OCD spectrum. Immunological therapies should be restricted to a few cases. While PANDAS has found no confirmation as a distinct syndrome, and it is not presented in DSM-5, patients with acute onset OCD ...Continue Reading

References

Oct 17, 1998·The Psychiatric Clinics of North America·B A FallonJ A Nields
Oct 12, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·R NicolsonJ L Rapoport
Jul 24, 2001·The International Journal of Neuropsychopharmacology·H L Leonard, S E Swedo
Jun 26, 2002·Molecular Psychiatry·P J HoekstraR B Minderaa
Jun 24, 2003·Nature Medicine·Christine A KirvanMadeleine W Cunningham
Jul 29, 2003·Psychiatric Services : a Journal of the American Psychiatric Association·Alicia Kaplan, Eric Hollander
Jul 27, 1957·Journal of the American Medical Association·E WITEBSKYR W EGAN
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kurt L HoffmanW Ian Lipkin
Feb 27, 2004·Pediatric Neurology·Piero PavoneRosario R Trifiletti
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Roger Kurlan
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher R LoiselleHarvey S Singer
Apr 13, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Harvey S SingerFranz H Grus
May 4, 2004·The Journal of Clinical Psychiatry·Pieter J HoekstraCees G M Kallenberg
Dec 14, 2004·Psychiatry Research·Norbert MüllerMarianne Abele-Horn
May 25, 2005·Journal of Child and Adolescent Psychopharmacology·Pieter J HoekstraRuud B Minderaa
Jun 23, 2005·Journal of Child Neurology·Marjorie A GarveySusan E Swedo
Jul 2, 2005·Journal of Psychiatric Practice·A G MikhailD S Pine
Oct 4, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Russell C DaleAndre W J Church
Oct 7, 2005·Neurology·Harvey S SingerPhillip N Williams
Jan 4, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael DiamondThomas J Connor
Feb 4, 2006·Autoimmunity·Christine A KirvanMadeleine W Cunningham
Aug 1, 2006·Journal of Neuroimmunology·Christine A KirvanMadeleine W Cunningham
Nov 23, 2006·Journal of Psychiatric Research·Astrid MorerFrancesc Graus
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A KirvanMadeleine W Cunningham
Jul 31, 2007·Brain Research Reviews·Henri M Duvernoy, Pierre-Yves Risold
Dec 15, 2007·Journal of Child Neurology·Tugba Erener ErcanGulten Karasu
Dec 17, 2008·Future Microbiology·Ken B WaitesT Prescott Atkinson
Jul 25, 2009·Journal of Neuroimmunology·Colin GauseHarvey S Singer
Oct 2, 2009·Neurology·Donald L Gilbert, Roger Kurlan
Feb 12, 2010·European Eating Disorders Review : the Journal of the Eating Disorders Association·Brenda VincenziBryan Lask
Oct 5, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Veit RoessnerGunther Helms

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Citations

Jun 1, 2018·Continuum : Lifelong Learning in Neurology·Peggy M A Richter, Renato T Ramos
Oct 16, 2018·Expert Opinion on Pharmacotherapy·Giacomo Grassi, Stefano Pallanti
Jul 26, 2019·Nursing·Chelsea Melerine, Linda M Ledet
Apr 28, 2018·Current Neuropharmacology·Elisabetta Burchi, Stefano Pallanti
Jan 16, 2021·Journal of Experimental Pharmacology·Giacomo GrassiSilvia Pacini
Apr 11, 2021·Molecular Psychiatry·Alexandre ValléeJean-Noël Vallée
May 26, 2021·Psychological Medicine·Behrang MahjaniChristie Burton
Jul 27, 2021·Frontiers in Pediatrics·Manuel MurcianoAlberto Spalice
Jun 17, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hugues LamotheLuc Mallet

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